Effect of estrogen replacement plus low-dose alendronate treatment on bone density in surgically postmenopausal women with osteoporosis

The Journal of Clinical Endocrinology and Metabolism
Stefano PalombaPasquale Mastrantonio

Abstract

This prospective randomized, double-blind, placebo-controlled, clinical trial was performed to evaluate the effectiveness of estrogens plus low-dose alendronate on bone metabolism. A total of 150 surgically postmenopausal women with osteoporosis were randomized in three groups: group A, micronized E2 (2 mg/d) plus standard-dose alendronate (10 mg/d); group B, micronized E2 plus low-dose alendronate (5 mg/d); and group C, micronized E2 plus placebo (one tablet per day). In all women, bone mineral density (BMD) and serum bone metabolism markers were assessed at admission and every 6 months for 2 yr. After 2 yr, BMD significantly increased compared with baseline in all groups. The percentage BMD change was significantly higher in groups A and B than in group C. The differences in BMD detected between groups A and B were not statistically significant. Since the 6-month follow-up and throughout the study, serum osteocalcin and bone alkaline phosphatase levels and urinary deoxypyridinoline and pyrilinks-D excretion were significantly reduced in all groups. Serum bone alkaline phosphatase levels significantly decreased in groups A and B, without difference between them, in comparison with group C. In conclusion, in surgically postmeno...Continue Reading

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Citations

Mar 2, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Stefano PalombaFulvio Zullo
Jun 2, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Stefano PalombaFulvio Zullo
Jul 23, 2005·Current Osteoporosis Reports·Marie-Paul LecartJean-Yves Reginster
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Jul 26, 2011·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Mona ChitreAndreas Grauer
Oct 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Stefano PalombaFulvio Zullo
Jan 19, 2010·The Journal of Clinical Endocrinology and Metabolism·Mark J BollandIan R Reid
May 18, 2017·Nutrition Research Reviews·Eva GatineauLaurent Mosoni
Feb 1, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E M LewieckiB M Thorpe
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Apr 18, 2012·The Journal of Clinical Endocrinology and Metabolism·Stefano PalombaGiovanni Battista La Sala
May 24, 2007·The Journal of Clinical Endocrinology and Metabolism·Stefano PalombaFrancesco Orio
Feb 7, 2008·The Cochrane Database of Systematic Reviews·G A WellsP Tugwell

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