PMID: 9159167May 27, 1997Paper

Effect of estrogen upon cyclic ADP ribose metabolism: beta-estradiol stimulates ADP ribosyl cyclase in rat uterus

Proceedings of the National Academy of Sciences of the United States of America
Eduardo N ChiniT P Dousa

Abstract

Cyclic ADP ribose (cADPR) has been shown to trigger Ca2+ release from intracellular stores through ryanodine receptor/channel. In our previous study we observed that all-trans-retinoic acid stimulates cADPR synthesis by ADP ribose cyclase (ADPR cyclase) in cultured epithelial cells. We have now investigated whether cADPR may play a signaling role in action of beta-estradiol (E2), an archetypal steroid superfamily hormone, upon its major target organ, uterus, in vivo. Administration of E2 to gonadectomized rats (0.2 mg/kg per day for 7 days) resulted in an approximately Delta + 300% increase of ADPR cyclase activity in extracts from uterus, but in liver, brain, or skeletal muscle ADPR cyclase was unchanged. Most of the E2-stimulated uterine ADPR cyclase was associated with membranes. The higher ADPR cyclase activity in response to E2 was due to the increase of VMAX without change in Km. Simultaneous administration of estrogen antagonist tamoxifen (8 mg/kg per day) with E2 (0.2 mg/kg per day) prevented an increase in ADPR cyclase. In uterine extracts from E2-treated rats, the rate of cADPR inactivation by cADPR hydrolase and the activity of NADase was increased, but to a much lesser degree than activity of ADPR cyclase. Our resul...Continue Reading

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Citations

Nov 5, 1999·Archives of Biochemistry and Biophysics·M LiangT P Dousa
Nov 5, 2002·Archives of Biochemistry and Biophysics·Eduardo N ChiniWeronika Zielinska
Feb 24, 2001·Journal of Neurochemistry·H HigashidaT Kato
Dec 17, 2008·Current Opinion in Nephrology and Hypertension·William J Arendshorst, Tiffany L Thai
Nov 13, 2008·Physiological Genomics·Gustavo HelgueraEnrico Stefani
Aug 31, 2000·Microvascular Research·N LiA P Zou
Apr 6, 2005·Clinical Endocrinology·Yoshiyu TakedaHiroshi Mabuchi
Mar 20, 2004·Journal of Neurochemistry·Santina BruzzoneAntonio De Flora
May 13, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Joao CorreiaStephen Publicover
Aug 15, 2006·Fertility and Sterility·Richard A BillingtonArmando A Genazzani
Dec 26, 2001·Science's STKE : Signal Transduction Knowledge Environment·A Galione, G C Churchill
Jan 4, 2006·Molecular and Cellular Endocrinology·Soner DoganMathur S Kannan
Sep 2, 2004·American Journal of Physiology. Endocrinology and Metabolism·Michael ThompsonEduardo N Chini
Jun 13, 2000·Circulation Research·F G de ToledoT P Dousa
Apr 12, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Deepak A DeshpandeMathur S Kannan
Jun 27, 2006·Journal of Cellular and Molecular Medicine·Andrew Y Zhang, Pin-Lan Li
Oct 12, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Thomas A WhiteMathur S Kannan
Jan 29, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Thomas A WhiteTimothy F Walseth
Sep 20, 2000·American Journal of Physiology. Heart and Circulatory Physiology·J Z YuP L Li
Mar 15, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Pin-Lan LiWilliam B Campbell
May 9, 2002·American Journal of Physiology. Cell Physiology·Eduardo N Chini, Frederico G S De Toledo
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Jan 15, 2002·Experimental Biology and Medicine·Ahad N K YusufiJoseph P Grande
Oct 23, 1997·Biochemical and Biophysical Research Communications·F G de ToledoT P Dousa
Jun 22, 1999·Cellular Signalling·A H Guse
Jan 27, 2005·Pharmacology & Therapeutics·Ni BaiIsmail Laher
Jul 19, 2006·Archives of Biochemistry and Biophysics·Sertac N KipGary C Sieck

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