PMID: 23Sep 1, 1975

Effect of etafenone on total and regional myocardial blood flow

H Flohr, W Breull


The distribution of blood flow to the subendocardial, medium and subepicardial layers of the left ventricular free wall was studied in anaesthetized dogs under normoxic (A), hypoxic (B) conditions and under pharmacologically induced (etafenone) coronary vasodilation (C). Regional myocardial blood flow was determined by means of the particle distribution method. In normoxia a transmural gradient of flow was observed, with the subendocardial layers receiving a significantly higher flow rate compared with the subepicardial layers. In hypoxia induced vasodilation this transmural gradient of flow was persistent. In contrast a marked redistribution of regional flow was observed under pharmacologically induced vasodilation. The transmural gradient decreased. In contrast to some findings these experiments demonstrate that a considerable vasodilatory capacity exists in all layers of the myocardium and can be utilized by drugs. The differences observed for the intramural distribution pattern of flow under hypoxia and drug induced vasodilation support the hypothesis that this pattern reflects corresponding gradients of regional myocardial metabolism.

Related Concepts

Diastolic Blood Pressure
Carbon Dioxide
Cardiac Output
Coronary Circulation
Sinus Node Artery
Canis familiaris
Pulse Rate
Heart Septum

Related Feeds


Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

European Journal of Applied Physiology and Occupational Physiology
J L Pannier, I Leusen
International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology
M RubartN Hahn
European Heart Journal Cardiovascular Imaging
Wei YuYiu-fai Cheung
Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova
A S TsvetkovaD N Shmakov
© 2021 Meta ULC. All rights reserved