Effect of ethamsylate on carrageenan-induced rat paw oedema: a comparison with indomethacin

Clinical and Experimental Pharmacology & Physiology
P R Gard, D J Trigger

Abstract

1. Ethamsylate (diethylammonium 2,5-dihydroxybenzene sulfonate, Dicynene), a systemic haemostatic agent with an unknown mechanism of action, was tested for anti-inflammatory activity using the carrageenan-induced rat paw oedema test. 2. Ethamsylate was shown to be an effective anti-inflammatory agent with a time course and amplitude of effect similar to that of indomethacin, although the potency was only about 4% of that for indomethacin. 3. When ethamsylate and indomethacin were co-administered they did not show additive effects, suggesting that they do not share a common mode of action. It is proposed that ethamsylate, like indomethacin, may inhibit prostaglandin synthesis. Ulceration produced by indomethacin, it is suggested that it may prove to be a useful addition to, or replacement for, indomethacin in the treatment of inflammatory disorders.

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Citations

Aug 1, 1992·Irish Journal of Medical Science·R F Harrison, M Devitt
Aug 18, 1995·Early Human Development·J T Wells, L R Ment
Apr 8, 2003·European Journal of Pharmacology·Patrick HannaertRicardo P Garay
Jun 15, 2006·American Journal of Therapeutics·Ricardo P GarayPatrick Hannaert

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