Effect of ethanol feeding upon levels of a male-specific hepatic estrogen-binding protein: a possible mechanism for feminization

Alcoholism, Clinical and Experimental Research
P K EagonD H Van Thiel

Abstract

Male, but not female, rat liver cytosol contains an estrogen-binding protein with unique properties: rapid binding of estradiol, high binding capacity, moderate affinity for estradiol, and specificity for steroidal estrogens and weak androgens, but not for nonsteroidal estrogens or other steroids. The estradiol-binding activity of this protein is reduced in cytosol from livers of alcohol-fed rats as compared to that from their isocalorically fed controls. The properties of this male-specific hepatic estrogen-binding protein suggest a role for this protein in the regulation of estrogen levels in the male animal. Moreover, the reduction in activity of this unique protein in the liver of alcohol-fed animals may explain, at least in part, the feminization commonly seen in chronic alcoholic men.

References

Sep 1, 1975·Metabolism: Clinical and Experimental·D H Van ThielG D Braunstein
Oct 1, 1979·Endocrinology·D H van ThielR Lester
Jun 1, 1975·The Journal of Clinical Endocrinology and Metabolism·G G GordonA L Southren
May 1, 1973·Metabolism: Clinical and Experimental·A L SouthrenW S Rosenthal
May 1, 1980·Archives of Biochemistry and Biophysics·P K EagonR Lester

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Citations

Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·R A AndersonL J Zaneveld
Jan 1, 1989·Pharmacology & Therapeutics·D H Van ThielR E Tarter
Sep 25, 1999·Clinics in Dermatology·R Wolf
May 5, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S D TadicP K Eagon
Jan 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A Galvaõ-TelesD H Van Thiel
Nov 1, 1990·Journal of Hepatology·F FarinatiR Naccarato
Jan 1, 1983·Alcoholism, Clinical and Experimental Research·Y B Chiao, D H Van Thiel
Jan 1, 1983·Alcoholism, Clinical and Experimental Research·P K EagonD H Van Thiel
Jan 1, 1982·Alcoholism, Clinical and Experimental Research·J S Gavaler
Apr 29, 2010·Current Diabetes Reports·Frank L Greenway, George A Bray
Apr 25, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·C N BoozerJ L Solomon
May 29, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·C N BoozerT Meredith
Feb 6, 1998·Journal of Clinical Gastroenterology·A ChowdhuryS Chowdhury
Sep 25, 1999·Clinics in Dermatology·A Shulman, R Wolf
Jan 1, 1989·Archives of Biochemistry and Biophysics·P K EagonD H Seeley

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