Effect of ethanol, haloperidol, and lorazepam on cardiac conduction and contraction

Journal of Cardiovascular Pharmacology
R P MedlinJ A Kline

Abstract

Haloperidol and lorazepam are commonly used to sedate ethanol (E)-intoxicated patients in emergency departments. This study was conducted to explore the role of ethanol in altering the potency of haloperidol and lorazepam with respect to cardiac conduction and contraction. For mechanical studies, isolated rat hearts were studied under isovolumetric conditions by using standard Langendorff technique. Hearts were perfused with Krebs-Heinseleit-Bicarbonate buffer containing haloperidol or lorazepam in concentrations ranging from 100 to 750 ng/ml (one heart per drug concentration). For both haloperidol and lorazepam individually, significant reductions in Left ventricular-generated pressure (LVGP) were observed at a concentration of 750 ng/ml (haloperidol = 2,250 nM and lorazepam = 2,000 nM). The addition of 20 and 65 mM ethanol shifted the concentration-response effect of haloperidol such that LVGP was significantly reduced at haloperidol = 500 and 300 ng/ml, respectively (p < 0.05 vs. basal control; paired t test). Ethanol produced no observable shift on the lorazepam concentration-response for LVGP. For electrophysiologic studies, hearts were perfused with haloperidol and lorazepam (300 ng/ml) +/- 65 mM ethanol. Compared with ba...Continue Reading

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Citations

Dec 19, 2008·American Journal of Therapeutics·Jamil DarroujRohit Arora
Dec 24, 2009·Canadian Journal of Physiology and Pharmacology·Katerina FialovaMarie Novakova
Jun 23, 2015·The Tohoku Journal of Experimental Medicine·Tibor StracinaMarie Novakova

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