Effect of ethanol on endogenous rhythms of growth hormone secretion

Alcoholism, Clinical and Experimental Research
G P Redmond

Abstract

Studies in man on the effect of ethanol on growth hormones (GH) release have been inconclusive. In order to investigate the effect of ethanol on spontaneous episodic secretion of GH, rats were implanted with chronic carotid catheters to permit frequent sampling in unanesthetized rats. Secretion during the 3 hr before (0--180 min) and after (181--360 min) ethanol or saline was assessed by means of samples drawn every 15 min. Secretion patterns after saline or ethanol 0.5 and 2 g/kg were indistinguishable, but ethanol in doses of 3 and 4 g/kg abolished rat GH (rGH) secretion in a majority of animals. Mean rGH after saline injection for the period 181--360 min was 62 +/- 9 ng/ml. When ethanol was given, mean rGH values for this time period were 0.5 g/kg, 63 +/- 6 ng/ml; 2.0 g/kg, 47 +/- 7 ng/ml; 3 g/kg, 28 +/- 3 ng/ml; and 4 g/kg, 23 +/- 2 ng/ml. Differences were not statistically significant between saline and 0.5 or 2 g/kg ethanol, but were significant (p less than 0.01) for 3 or 4 g/kg ethanol. Thus, a single dose of ethanol can abolish spontaneous rGH secretion, but it must be a high dose. The effect of chronic ethanol administration remains to be investigated.

References

May 14, 1977·Lancet·R Frajria, A Angeli
Dec 1, 1975·Acta Physiologica Scandinavica·J LeppäluotoT Ranta
Jul 1, 1978·Alcoholism, Clinical and Experimental Research·T J CiceroT M Badger
Jul 1, 1978·Alcoholism, Clinical and Experimental Research·O P GandaM L Mitchell
May 1, 1979·The Journal of Clinical Endocrinology and Metabolism·L P PlotnickA A Kowarski
Dec 1, 1978·The Journal of Pediatrics·A BinkiewiczB Senior
Oct 1, 1975·The Journal of Pediatrics·A W RootG Duckett
Jan 1, 1976·The Journal of Clinical Endocrinology and Metabolism·G TamburranoD Andreani
Apr 1, 1976·Metabolism: Clinical and Experimental·H A PriemC Malan
Jun 29, 1968·British Medical Journal·J S Jenkins, J Connolly
Apr 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·V L GayA R Midgley

❮ Previous
Next ❯

Citations

Mar 9, 1999·Alcoholism, Clinical and Experimental Research·V K SrivastavaW L Dees
Jan 1, 1988·Endocrine Research·M A EmanueleA M Lawrence
Apr 1, 1992·Experimental and Molecular Pathology·P M IngletonM A Parsons
Jan 1, 1983·Alcoholism, Clinical and Experimental Research·M VälimäkiR Ylikahri
Mar 9, 2002·Toxicology and Applied Pharmacology·Shuxin ZhangWayne L Backes
Jan 1, 1982·Alcoholism, Clinical and Experimental Research·T J Cicero
Feb 1, 1989·Alcoholism, Clinical and Experimental Research·W E Sonntag, R L Boyd

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.