PMID: 2507454Oct 15, 1989Paper

Effect of ethanol on hepatocarcinogenesis initiated in rats with 3'-methyl-4-dimethylaminoazobenzene in the absence of liver injuries

International Journal of Cancer. Journal International Du Cancer
S YanagiT Kamiya

Abstract

In this study special care was taken to discriminate between the direct effect of ethanol on hepatocarcinogenesis and secondary effects such as choline deficiency or fatty liver. Rats were divided into 2 groups, D and N. Group D was initiated using 3'-Me-DAB, while the control group N was not initiated. Groups N and D were divided into 4 sub-groups. Each subgroup was given, in the drinking water, one of the following ethanol solutions: 0, 5, 10 or 15% for 45 weeks. Liver tumors were induced only in D groups. Evidence obtained indicates that: (a) in the N group, ethanol did not cause any apparent disorders in histology and lipid metabolism, and (b) in the D group no significant differences were observed in the incidence of HCCs and other liver lesions. Ethanol thus does not appear to enhance hepatocarcinogenesis, at least in the absence of liver injury.

References

Jan 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A TakadaY Matsuda
Mar 15, 1986·International Journal of Cancer. Journal International Du Cancer·S YanagiT Nakano
Jan 1, 1986·Annual Review of Nutrition·M C Mitchell, H F Herlong
Jan 1, 1988·Annual Review of Nutrition·H K Seitz, U A Simanowski
Mar 1, 1986·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H E Driver, A E McLean
Nov 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E A PortaR D Dorado
Jun 1, 1965·The Journal of Clinical Investigation·C S LIEBERL M DECARLI

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Citations

Mar 12, 1992·International Journal of Cancer. Journal International Du Cancer·K X XueY Q Wang

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