Effect of etoposide (VP16-213) on lipid peroxidation and antioxidant status in a high-dose radiochemotherapy regimen

Cancer Chemotherapy and Pharmacology
C LadnerM R Clemens


A total of 13 patients receiving bone marrow transplants (BMT) for treatment of different haematological diseases were investigated. Conditioning therapy preceding BMT consisted of fractionated total-body irradiation (12 Gy) and high-dose chemotherapy with cyclophosphamide (2 +/- 60 mg/kg). Patients stratified to be at high risk for relapse (6/13) were additionally treated with etoposide (30 mg/kg). Plasma concentrations of absolute and lipid-standardized antioxidants (alpha-tocopherol and beta-carotene) decreased following conditioning therapy, presumably as the result of an enhanced breakdown of these antioxidants. Etoposide treatment did not amplify the loss of essential anti-oxidants but significantly increased lipid hydroperoxide concentrations in serum. We suggest that the abnormal generation of lipid hydroperoxides is the result of free radical formation.


Jun 1, 1989·Journal of Clinical Pharmacy and Therapeutics·M E Abdel-HamidM M Hasan
Jan 1, 1986·Free Radical Research Communications·J M van MaanenH M Pinedo
Jan 1, 1988·Free Radical Research Communications·J M van MaanenH M Pinedo
Jan 1, 1987·Chemico-biological Interactions·A G KatkiB K Sinha
May 1, 1987·The American Journal of Clinical Nutrition·K F GeyH B Stähelin
Nov 15, 1983·Biochemical Pharmacology·B K SinhaB Kalyanaraman
May 11, 1984·Science·G W Burton, K U Ingold


Feb 14, 2002·Archives of Biochemistry and Biophysics·Sema SentürkerEmily Shacter
Mar 5, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Abhilasha GuptaAnand N Srivastava
Jul 1, 1997·Cancer Treatment Reviews·N I WeijlS Osanto
Jul 23, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S M AttiaSaleh A Bakheet
Jan 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elena J LadasKara M Kelly
Jun 24, 2003·Journal of Inorganic Biochemistry·Evelyne L Weaver, Rathindra N Bose
Feb 18, 2006·Integrative Cancer Therapies·Ralph W Moss
Jul 19, 2011·Bone Marrow Transplantation·S SabuncuoğluH Ozgüneş
Jun 1, 1992·Zeitschrift für Ernährungswissenschaft·M R ClemensK F Gey
Jan 18, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hannah E GreenwoodTimothy H Witney
Nov 19, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yong-Qiang LiuYong-Xian Cheng
Dec 26, 2001·Chemical Reviews·E Wong, C M Giandomenico

Related Concepts

Hypoplastic Anemia
Antioxidant Effect
Combined Modality Therapy
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