PMID: 9558518Apr 29, 1998Paper

Effect of eugenol on macrophage adhesion in vitro to plastic surfaces

Endodontics & Dental Traumatology
J J Segura, A Jiménez-Rubio

Abstract

This study was performed to investigate the in vitro effect of eugenol on substrate adherence capacity of macrophages. Macrophages were obtained from Wistar rats. The adherence capacity of macrophages to the plastic surface of Eppendorf tubes was determined. Assays were carried out in these tubes for 15 min of incubation at 37 degrees C in a humidified atmosphere of 5% CO2 in air. Control peritoneal macrophages showed an adherence index = 52.5%. Eugenol decreased the adherence index of macrophages in a dose-dependent manner. A 1:1000 dilution of eugenol decreased the adherence index of macrophages by 16.6% (P < 0.05). Lower dilutions (1:100 and 1:10) greatly decreased the adherence index by 51% and 96.2% respectively (P < 0.01). Taking into account that substrate adherence is the first step in the phagocytic process of macrophages and in antigen presentation, eugenol could inhibit macrophage function and modulate immune and inflammatory reactions in dental pulp and periapical tissues.

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Citations

Aug 3, 2001·Australian Endodontic Journal : the Journal of the Australian Society of Endodontology Inc·W Geurtsen
Apr 20, 2004·Drug Development and Industrial Pharmacy·Bhimrao K JadhavSambhaji S Pisal
Jul 22, 2010·Journal of Endodontics·Maribel González-MartínJuan José Segura-Egea
Dec 8, 2009·Journal of Dentistry·Li-Hong HeMichael V Swain
Jun 19, 2015·Dental Traumatology : Official Publication of International Association for Dental Traumatology·Julia Mourão BragaAntonio Paulino Ribeiro Sobrinho
Feb 27, 2007·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Edilson José ZafalonPaula Dechichi
Dec 10, 2002·Journal of Endodontics·T SchwarzeW Geurtsen
Feb 5, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Emilio CarpioIralys Benítez
Feb 25, 2003·Journal of Endodontics·Sônia Teresa de Oliveira MendesLeda Quercia Vieira
Jun 29, 2004·Journal of Endodontics·Saud Al-AwadhiLynne A Opperman

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