Effect of excess dietary histidine on rate of turnover of 65Zn in brain of rat

Biological Trace Element Research
J Wensink, C J Van den Hamer

Abstract

The effect of the chronic administration of histidine on the brain zinc level was examined in growing, male Wistar rats. Using a purified diet, the minimum zinc requirement for normal growth and normal plasma and tissue zinc levels was found to be around 10 ppm. Given this zinc content, the diet was supplemented with 5% and 8% histidine, respectively, or with 10% glycine (as control). Brain zinc was analyzed by measuring the rate of turnover of 65Zn from 2-4 weeks after a single injection of the tracer. Feeding the diet supplemented with 5% histidine caused a small decrease in the plasma zinc concentration and a slight increase in the rate of turnover of 65Zn in the cerebrum and the cerebellum as compared to the control group. The animals fed the diet supplemented with 8% histidine became severely zinc deficient (as evidenced by a 50% reduction in the plasma zinc content), however, the rate of turnover of 65Zn in all brain regions examined was significantly decreased as compared to the control group. The results indicate that histidine has no specific complexing action on the brain zinc.

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Citations

Mar 1, 1990·Biological Trace Element Research·J P Van WouweC J Van den Hamer
Oct 1, 1989·Biological Trace Element Research·J P Van WouweC J Van den Hamer
Oct 1, 1989·Biological Trace Element Research·J WensinkC J Van den Hamer
Jan 1, 1992·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·S P AikenN R Saunders
Jun 7, 2005·Urological Research·J A Muñoz, M Valiente
Jan 1, 1995·International Urology and Nephrology·F GrasesA Costa-Bauzá
Jan 1, 1997·World Journal of Urology·W Achilles
Jan 1, 1990·Urological Research·F Hering
Jan 1, 1990·Urological Research·R J McLeanJ C Nickel
Jul 7, 2020·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Fabiola Pizzo

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