PMID: 6411875Sep 1, 1983Paper

Effect of excess dietary lysine on plasma lipids of the chick

The Journal of Nutrition
D D SchmeisserD H Baker

Abstract

Feeding diets with 4% L-lysine to the chick produces an elevation of plasma lipids which does not occur when feeding an excess of any other amino acid. Experiments were conducted to determine whether lysine-induced hyperlipidemia is secondary to the antagonistic effect of lysine on arginine or to the anorexia which accompanies lysine feeding, and in addition, whether the lysine-induced hypercholesterolemia is affected by chick age. In all experiments gain and food intake were reduced by feeding chicks 4% lysine. Plasma cholesterol and triglyceride were elevated, but high-density-lipoprotein cholesterol, as a percentage of total, was reduced. Addition of dietary arginine up to 4% failed to reverse the depression in performance and elevation of plasma lipids. Pair-feeding the control diet to the amount consumed by lysine-fed chicks did not elevate plasma lipids above control levels. Thus, lysine-induced hyperlipidemia is not mediated by the antagonistic effect of lysine on arginine nor by the effect of lysine on food intake. The high-lysine diet prevented the normal decline in plasma cholesterol expected with advancing age of chicks. Preliminary results suggested that excess lysine stimulated cholesterol biosynthesis.

Citations

Jan 1, 1985·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·S Kitajima, Y Kishino
Sep 3, 2016·Bioinformatics·Jaehoon LeeTaesung Park
Aug 1, 1992·Comparative Biochemistry and Physiology. Comparative Physiology·Y AkibaH Ohkawara

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