Effect of exercise and exogenous glucocorticoid on serum level of intact parathyroid hormone

International Journal of Sports Medicine
K S TsaiC H Yang

Abstract

Most previous studies suggest that physical exercise, or physiological response to exercise such as cortisol and adrenaline secretion regulate parathyroid hormone (PTH) secretion in humans. To investigate the effects and possible interaction of exercise and excessive glucocorticoid on PTH secretion, we examined the serum of levels of intact-PTH, cortisol, adrenocorticotrophic hormone (ACTH), calcium, magnesium and phosphorus before and during one-hour of bicycle-ergometric exercise at 60% of maximal oxygen uptake. These exercise tests were performed on eight Chinese male volunteers aged between 20 and 25 years, once with and once without pretreatment with 0.5 mg of dexamethasone taken orally 9.5 hours in advance. The results showed that dexamethasone pretreatment significantly lowered basal levels of cortisol and ACTH, but intact PTH did not change. After 60 minutes of bicycling, intact PTH level increases by 50% of baseline both with and without dexamethasone pretreatment. Serum levels of calcium, corrected for changes in serum albumin concentration, phosphorus and magnesium also increased in both cases. This study demonstrated an increase of intact-PTH with exercise which was not associated with hypocalcemia or hypomagnesemia...Continue Reading

Citations

Sep 18, 2009·Calcified Tissue International·Laurent Maïmoun, Charles Sultan
May 8, 2013·Scandinavian Journal of Medicine & Science in Sports·G LombardiG Banfi
Dec 30, 2014·Research in Veterinary Science·Scott KilpatrickRichard J Mellanby
Mar 24, 2010·Medicine and Science in Sports and Exercise·Christina D SchwindtDan M Cooper
Jun 19, 2008·American Journal of Physiology. Endocrinology and Metabolism·Cedric MoroMichel Berlan
Mar 23, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Cedric MoroMichel Berlan
Jun 1, 2005·Journal of Pediatric Endocrinology & Metabolism : JPEM·Alberto VerrottiFrancesco Chiarelli
Jan 1, 2013·Journal of Sports Medicine·Shannon L MathisJennifer L Caputo

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