Effect of exercise, DDAVP, and epinephrine on the factor VIII:C/von Willebrand factor complex in normal dogs and von Willebrand factor deficient Doberman pinscher dogs

Thrombosis Research
K M MeyersJ Brassard

Abstract

Endothelial cells in biopsied blood vessels from von Willebrand factor (vWf)-deficient Doberman pinscher dogs contain immunologically detectable vWf. These dogs and normal dogs were treated with DDAVP (0.6 microgram/kg) and epinephrine (0.5 microgram/kg/min for 30 minutes) and were exercised, using 5 different exercise protocols, (3-4 m/s for 5-40 minutes at 0-5% grade) to determine if treatments reported to increase plasma factor VIII:C/vWf complex in humans would elevate canine plasma vWf. Following the two most strenuous exercise conditions--30 and 40 minutes--plasma von Willebrand factor antigen (vWf:Ag) increased in normal dogs by 30% and 70%, respectively. Factor VIII:C was increased 47% by the most strenuous exercise conditions. The vWf-deficient dogs would not exercise beyond 30 minutes and neither vWf:Ag nor factor VIII:C activity increased. Following DDAVP, plasma vWf:Ag increased in the normal dogs by 47% and factor VIII:C activity was increased by 48%. Factor VIII:C activity increased by 30% in the vWf-deficient dogs, but there was only a slight change in vWf:Ag. Bleeding time decreased in 5 of 6 vWf-deficient dogs. In the normal dogs vWf:Ag increased by 14% after epinephrine infusion, but factor VIII:C activity did...Continue Reading

References

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Citations

Jun 9, 2005·American Journal of Veterinary Research·Mary Beth CallanJames L Catalfamo
Dec 1, 1995·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·J S ChoJ Stoughton
Jul 5, 2008·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Mariko YabeYasuo Ikeda
Jun 20, 2008·Journal of Veterinary Internal Medicine·T A PetanidesS Lekkas
Mar 6, 2012·American Journal of Hematology·Paula D James, David Lillicrap
Jun 26, 2020·Frontiers in Veterinary Science·Tomoko IwanagaRobert Goggs

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