PMID: 3320007Oct 1, 1987Paper

Effect of exercise on insulin binding and glucose transport in adipocytes of normal humans

Journal of Applied Physiology
V A Koivisto, H Yki-Järvinen

Abstract

Acute exercise increases insulin binding to its receptors on blood cells. Whether the enhanced insulin binding explains the exercise-induced increase in glucose uptake is unclear, since insulin binding and glucose uptake have not been measured simultaneously in a target tissue of insulin. In this study, we determined insulin binding and the rate of glucose transport in adipocytes obtained by needle biopsy from 10 healthy men before and after 3 h of cycle-ergometric exercise. During the exercise, plasma glucose (P less than 0.01) and insulin (P less than 0.001) fell and serum free fatty acid level rose 4.3-fold (P less than 0.001). 125I-insulin binding to adipocytes remained unchanged during exercise. The rate of basal glucose transport clearance fell from 28.1 +/- 5.7 fl.cell-1.s-1 to 22.9 +/- 5.6 fl.cell-1.s-1 (P less than 0.005), and the insulin-stimulated increase in glucose transport rate rose from 196 +/- 26 to 279 +/- 33% (P less than 0.025) during the exercise. Thus, in the adipocytes during exercise, the basal glucose transport rate and the responsiveness of glucose transport to insulin changed in the absence of alterations in insulin binding. These data indicate that the exercise-induced changes in insulin binding show...Continue Reading

Citations

Jun 1, 1995·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·J K Shoemaker, A Bonen
Jan 2, 2001·Endocrine Reviews·S MatthaeiH U Häring
Apr 1, 1992·European Journal of Clinical Investigation·J W KolaczynskiV A Koivisto
Jan 1, 1990·European Journal of Applied Physiology and Occupational Physiology·E CacciariR Pini

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