Effect of exercise training on clot strength in patients with peripheral artery disease and intermittent claudication: An ancillary study

SAGE Open Medicine
Karin MauerAndrew W Gardner

Abstract

Patients with peripheral artery disease have walking impairment, greater thrombotic risk, and are often treated with exercise training. We sought to determine the effect of a 3-month-long exercise program on clot strength among patients with peripheral artery disease and intermittent claudication. Twenty-three symptomatic peripheral artery disease patients were randomly assigned to a walking exercise program or to an attention control group who performed light resistance exercise. We investigated the effect of exercise training on clot strength and time to clot formation was assessed by thromboelastography. After 3 months of exercise, clot strength (maximal amplitude) and time to clot formation (R) did not change significantly from baseline, even after improvements in claudication onset time (p < 0.01) and peak walking time (p < 0.05). Furthermore, changes in clot formation parameters were not significantly different between groups. Among the 10 individuals demonstrating a reduction in clot strength (reduced maximal amplitude), one was a smoker (10%) compared to 9 of 13 non-responders (69%) whose maximal amplitude was unchanged or increased (p = 0.0097). In this ancillary study, a 12-week walking program improved ambulatory fun...Continue Reading

References

Apr 1, 1991·Medicine and Science in Sports and Exercise·A W GardnerL K Smith
Jan 1, 1994·Advances in Experimental Medicine and Biology·P HickmanP T McCollum
Jun 13, 1998·Journal of the American Geriatrics Society·P S Montgomery, A W Gardner
Feb 28, 2004·Sports Medicine·Mahmoud S El-SayedSajad Ahmadizad
Oct 9, 2004·Journal of Vascular Surgery·Lois A KillewichAndrew W Gardner
Oct 14, 2006·Vascular and Endovascular Surgery·Andrew W Gardner, Polly S Montgomery
Mar 16, 2007·European Journal of Clinical Investigation·A Blinc, P Poredos
Mar 28, 2007·Cleveland Clinic Journal of Medicine·Mary McGrae McDermott
Apr 7, 2007·Medicine and Science in Sports and Exercise·Michael M LockardJames M Hagberg
May 15, 2007·Journal of the American College of Cardiology·Deepak L BhattUNKNOWN CHARISMA Investigators
Jun 22, 2007·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Günther SumannWolfgang Schobersberger
Jun 27, 2007·International Heart Journal·Tayfun AcilSerdar Aksoyek
Dec 19, 2007·Circulation·Wayne RosamondUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Nov 22, 2008·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Kathleen Menzel, Thomas Hilberg
Feb 24, 2010·Clinical Physiology and Functional Imaging·Haruhiko MadarameToshiaki Nakajima
Dec 15, 2012·European Journal of Applied Physiology·Thomas HilbergUdo F Wehmeier
Feb 23, 2013·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Vance G NielsenEvangelina B Steinbrenner
Apr 27, 2013·Journal of Applied Physiology·Manfred LamprechtGerhard Cvirn
Jul 4, 2013·JAMA : the Journal of the American Medical Association·Mary M McDermottW Jack Rejeski
Jul 12, 2013·Journal of Thrombosis and Thrombolysis·Akira SuehiroJunichiro Yamamoto

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Citations

Jul 23, 2016·Experimental Biology and Medicine·Nikolaos PatelisSean Metheiken
Apr 9, 2018·The Cochrane Database of Systematic Reviews·David HagemanJoep Aw Teijink
Apr 24, 2021·Journal of the American Heart Association·Shivshankar ThanigaimaniJonathan Golledge

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Clinical Trials Mentioned

NCT00618670

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