PMID: 11323539Apr 27, 2001Paper

Effect of exercise training on metallothionein levels of hypertensive rats

Medicine and Science in Sports and Exercise
S Bobillier ChaumontA Berthelot

Abstract

Because oxidative stress may be involved in arterial hypertension by affecting the balance between relaxing and contracting factors of vascular smooth muscle, the training-induced adaptation of antioxidant defenses could be implicated in the antihypertensive effect of chronic exercise. It has been suggested that metallothionein (MT), a metal-binding protein, plays an antioxidant role in mammals. The aim of this experiment was to study whether chronic exercise (swimming) influences both the development of arterial hypertension in spontaneously hypertensive rats (SHR) and the modification of MT levels. Male SHR and Wistar Kyoto (WKY) rats as control were trained to swim 1 h.d-1 5 d.wk-1 for 8 wk and sacrificed 72 h after the last exercise period. MT and total thiol levels were then measured. Exercise training 1) reduced systolic blood pressure and heart rate in both SHR WKY rats, and 2) was associated with a decrease in hepatic and cardiac MT levels; there was an increase in the aortic MT amounts in exercised SHR only. No modifications were noted in the gastrocnemius muscle or kidneys. In exercised animals, total thiols were lower in the liver but not in kidneys. Chronic exercise induced a reduction in arterial hypertension devel...Continue Reading

Citations

May 31, 2003·Canadian Journal of Physiology and Pharmacology·Fatiha ElhaïmeurAlain Berthelot
Jan 11, 2005·Experimental Physiology·Milena PenkowaBente Klarlund Pedersen
May 20, 2003·Development, Growth & Differentiation·Nathan L BrownJonathan R Sandy
Nov 15, 2006·European Journal of Applied Physiology·Marzena Podhorska-OkolowMaciej Zabel
Jun 28, 2012·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L C CarnevaliM C L Seelaender
Apr 11, 2020·Redox Biology·Juan Diego Hernández-CamachoIgnacio Navas-Enamorado
Jun 20, 2006·Explore : the Journal of Science and Healing·DeAnn LiskaDavid S Jones

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