Effect of exercise training volume on arterial contractility and BK(Ca) channel activity in rat thoracic aorta smooth muscle cells.

European Journal of Applied Physiology
Lijun ShiXiaodong Liu

Abstract

Large-conductance Ca(2+)-activated K(+) (BK(Ca)) channels play a critical role in regulating cellular excitability and vascular tone. Exercise training showed reversible beneficial effects on cardiovascular systems with an improvement of vascular functions. This study investigated the effects of exercise training volume on vascular function and BK(Ca) channel activity in thoracic aorta smooth muscle cells (SMCs) in 20 sedentary (SED) and 40 training rats, submitted to a treadmill training protocol (20 m/min, 60 min/day, 12 weeks). Training rats were divided into two groups, exercising 3 days/week (EX1) and 5 days/week (EX2). Since intensity and duration of exercise were identical between training groups, the training volume was higher in EX2 than in EX1. Exercise training not only decreased heart rate, but also attenuated pressor responses induced by angiotensin II or norepinephrine (NE). The maximal vascular contraction induced by 10(-5) M NE was significantly decreased after training. In precontracted thoracic aorta with NE (10(-5) M), activation of the BK(Ca) channels by NS1619 significantly decreased the tension. The sensitivity of tissue to NS619 (pD2) was significantly correlated with volume of training (SED < EX1 < EX2)....Continue Reading

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