Effect of exogenous factors on bacteriocin production from Lactobacillus paracasei J23 by using a resting cell system

International Journal of Molecular Sciences
Huaxi YiFang Ma

Abstract

A resting cell system was developed for bacteriocin Lac-B23 production from Lactobacillus paracasei J23. The resting cell medium contained (g/L): Glucose 20, Sodium acetate 5.0, MnSO4 0.25 MgSO4 0.5, Ammoniumhydrogencitrate 1.0, KH2PO4 1.0. The resting cell incubation time and temperature were 20 h and 37 °C and the effects of exogenous factors, including amino acids, glycerol, pyruvic acid, and α-ketoglutaric acid were investigated. Cys and Gly could stimulate the production of bacteriocin, while no stimulus effect was observed for Glu, Tyr and Ala. Glycerol and pyruvic acid increased bacteriocin production and the optimum concentrations were 1% and 30 g/L, respectively. Bacteriocin could act as an inducer of its own biosynthesis. These findings are of importance for the further study of bacteriocin biosynthesis regulation and for the improvement of bacteriocin production yields.

References

Feb 15, 2002·International Journal of Food Microbiology·Frédéric Leroy, Vuyst Luc De
Aug 26, 2006·Archives of Microbiology·Trinelise BlomqvistLeiv Sigve Håvarstein
Jun 20, 2007·Molecular Genetics and Genomics : MGG·Daniel StraumeDzung B Diep
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Feb 28, 2013·International Journal of Molecular Sciences·Georgia ZoumpopoulouKonstantinos Papadimitriou

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Citations

Sep 22, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mduduzi Paul Mokoena
Sep 4, 2021·Journal of Agricultural and Food Chemistry·Yushan BuHuaxi Yi
Nov 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mduduzi P MokoenaAdemola O Olaniran

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