PMID: 7021006Feb 1, 1981Paper

Effect of exogenous insulin on fasting serum levels of gastric inhibitory polypeptide (GIP) in juvenile diabetes

Clinical Endocrinology
M TalaulicarW Creutzfeldt

Abstract

The effect of insulin on fasting levels of immunoreactive gastric inhibitory polypeptide (IR-GIP) has been examined in insulin-dependent, juvenile-type diabetics who were well-controlled with two doses of an intermediate insulin. After withdrawal of the evening insulin injection the fasting blood glucose and serum IR-GIP levels were elevated and decreased significantly following intravenous insulin towards normal values. There was a significant positive correlation between levels of blood glucose and serum IR-GIP before and during insulin application. It is suggested that fasting serum GIP levels increase in case of insulin deficiency because basal GIP secretion is suppressed by normal insulin levels.

References

Feb 1, 1979·Diabetologia·W Creutzfeldt
Apr 1, 1978·Gut·M C KewT H Bothwell
Sep 1, 1978·The Journal of Clinical Endocrinology and Metabolism·J L BothaP T Child
Aug 1, 1979·The Journal of Clinical Endocrinology and Metabolism·C ReynoldsA H Rubenstein
Jun 1, 1976·The Journal of Clinical Endocrinology and Metabolism·S E CrockettE L Mazzaferri
Nov 1, 1973·The Journal of Clinical Endocrinology and Metabolism·J DupreJ C Brown
Dec 1, 1961·Klinische Wochenschrift·F H SCHMIDT

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