PMID: 9539194Apr 16, 1998Paper

Effect of exogenous insulin on protein metabolism with differing nonprotein energy intakes in Type 2 diabetes mellitus

International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
Réjeanne GougeonJosé A Morais

Abstract

To determine if insulin treatment combined with a generous protein intake would normalize whole-body protein kinetics and nitrogen balance in obese subjects with Type 2 diabetes mellitus when compared to obese nondiabetic subjects: 1) during weight-maintenance and 2) after a very low energy diet (VLED). Clinical intervention study of iso- followed by hypoenergetic feedings with or without exogenous insulin. Sixteen obese subjects with a body mass index (BMI) of 39+/-4 kg/m2, with Type 2 diabetes mellitus (three men, six women) or without (one man, six women). Nitrogen flux rate calculated from the urine 15N-urea enrichment by using the 60 h oral 15N-glycine method, rates of protein synthesis and breakdown calculated from nitrogen flux on days 6-8 (and 13-15 in the diabetic subjects) of isoenergetic feeding and days 24-26 of a 1.9 MJ diet. With insulin therapy: 1) during isoenergetic feeding, in the hyperglycaemic diabetic subjects, nitrogen balance was significantly less than in the obese controls (-0.6+/-0.6 compared with +1.8+/-0.9 g N/d, P = 0.037) but became positive (+2.6+/-0.6 g N/d, P < 0.05); nitrogen flux decreased and net protein synthesis increased from values different from those of the obese controls to values no l...Continue Reading

Citations

Mar 20, 2003·Current Diabetes Reports·Marion J Franz
Dec 2, 2008·Journal of Nutrition for the Elderly·Andrea R JosseCyril W C Kendall
Jun 25, 2013·Diabetes Technology & Therapeutics·Viknesh Prabu AnbalaganViswanathan Mohan
Oct 4, 2012·The Journal of Clinical Endocrinology and Metabolism·Kevin R ShortRita Basu
Jun 13, 2015·Experimental Gerontology·Jessica MurphyJosé A Morais
Jan 22, 2015·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Cherise C LabonteRéjeanne Gougeon
Mar 22, 2007·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Frantisek DuskaMichal Andel
Oct 9, 2007·Diabetes Care·Réjeanne GougeonErrol B Marliss
Jul 30, 2002·Diabetes·Panagiotis HalvatsiotisK Sreekumaran Nair
Oct 18, 2007·Diabetes·Sandra PereiraRéjeanne Gougeon
Jun 25, 2009·Diabetes Care·Seok Won ParkUNKNOWN Health, Aging, and Body Composition Study
Sep 25, 2004·Canadian Journal of Physiology and Pharmacology·Enoka P WijekoonJohn T Brosnan
Feb 1, 2005·Anesthesiology·Thomas SchrickerFranco Carli
Apr 28, 2005·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·J I MannUNKNOWN Diabetes and Nutrition Study Group (DNSG) of the European Association

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