PMID: 15248464Jul 14, 2004Paper

Effect of exogenous leptin administration on high fat diet induced oxidative stress

Die Pharmazie
J B Kalaivani SailajaNamasivayam Nalini

Abstract

The objective of the present study was to explore the tissue lipid peroxidation and antioxidant status in mice receiving exogenous leptin along with high fat diet for a period of 6 weeks. Significantly elevated levels of tissue thiobarbituric acid reactive substances (TBARS), conjugated dienes (CD) and significantly lowered levels of glutathione and its related enzymes were observed in the liver, heart and kidney of mice fed with a high fat diet as compared with the control mice fed with a standard pellet diet. Subsequent to the treatment with high fat diet (ie., after the initial period of 30 days) exogenous leptin (230 microg kg(-1) body weight) was simultaneously administered along with the regular high fat diet every alternate day for 15 days. Leptin administration significantly lowered the tissue levels of TBARS, CD and elevated the activities of reduced glutathione (GSH), glutathione peroxidase (GPx) and glutathione S-transferase (GST) in both the control and high fat diet fed mice. Thus leptin supplementation was found to be effective in attenuating high fat diet induced oxidative stress.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
V BalasubramaniyanNamasivayam Nalini
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Selvaraj Aranganathan, Namasivayam Nalini
© 2022 Meta ULC. All rights reserved