PMID: 44380Dec 1, 1979

Effect of exogenous serotonin on intragastric pH and its influence on serum gastrin levels in rats

Revista española de fisiología
J H HierroJ Peña


The effect of various doses of serotonin on the serum gastrin levels and intragastric pH in rats, was studied. After serotonin administration of 10 mg/kg i.p., a significant increase in serum gastrin levels was noted, as well as a strong increase in the intragastric pH. It was also observed that a lower dose, 5 mg/kg i.p., significantly increased serum gastrin levels, while intragastric pH was not affected, remaining at baseline values throughout the study. These results suggest that the increase observed in serum gastrin levels after administration of exogenous serotonin is not mediated by increase in intragastric pH.

Related Concepts

Gastric Juice
Serotonin Measurement
Structure of Pyloric Gland
Injections, Intraperitoneal
Hydrogen-Ion Concentration
Serum Gastrin Measurement

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