PMID: 7543173Aug 1, 1995Paper

Effect of exogenous testosterone replacement on prostate-specific antigen and prostate-specific membrane antigen levels in hypogonadal men

Journal of Surgical Oncology
T DouglasG P Murphy

Abstract

Previous studies have suggested that serum prostate-specific antigen (PSA) levels are under androgenic influence, especially in patients with adenocarcinoma of the prostate. PSMA (prostate-specific membrane antigen) is thought to reflect hormonal or clonal resistance or an independence with respect to testosterone regulation. The influence of testosterone on serum PSA expression in normal men is not clear. We studied the effect of exogenous testosterone administration on the serum levels of PSA and PSMA in hypogonadal men. Serial serum PSA, serum PSMA by Western blot, and serum total testosterone levels were obtained at intervals of every 2-4 weeks in 10 hypogonadal men undergoing treatment with exogenous testosterone, delivered as testosterone enanthate injection or by testosterone patch. Linear and quadratic orthogonal polynomial scores were calculated for PSMA, PSA, and testosterone. A 2-tailed, paired t-test failed to demonstrate a significant correlation between serum PSA (linear P = 0.432, quadratic P = 0.290) or PSMA (linear P = 0.162, quadratic P = 0.973) and serum testosterone levels. This study suggests that in hypogonadal men, neither PSMA nor PSA expression is testosterone-dependent.

References

Oct 22, 1992·The New England Journal of Medicine·G J GormleyJ S Tenover
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Citations

Jun 1, 1997·The Prostate·X GaoK V Honn
Jun 21, 2002·European Urology·Alvaro Morales
Jul 18, 2008·International Journal of Impotence Research·R ShabsighK M Slawin
Sep 8, 1998·Archives of Andrology·E Velázquez, G Bellabarba Arata
Mar 26, 2004·Clinical Prostate Cancer·Judd W Moul
Jun 17, 2015·Current Urology Reports·Kevin Matthew Yen Bing LeungSerge Carrier
Jun 15, 2013·The Journal of Urology·Jeffrey A PearlKevin T McVary
Feb 25, 2000·The Journal of Urology·A MoralesC C Carson
Dec 21, 2016·Investigative and Clinical Urology·Niranjan J SathianathenDeclan G Murphy
Jul 21, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Steven M PetakUNKNOWN American Association of Clinical Endocrinologists

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