Effect of Expedited Microneedle-Assisted Photodynamic Therapy for Field Treatment of Actinic Keratoses: A Randomized Clinical Trial

JAMA Dermatology
Tatyana A PetukhovaRaja K Sivamani

Abstract

Photodynamic therapy (PDT) is an effective and cosmetically favorable treatment modality for actinic keratoses (AKs). However, prolonged incubation times and pain associated with treatment are burdensome to the patient and a hindrance to widespread use of PDT as standard field therapy for AK. To evaluate efficacy and pain associated with microneedle expedited PDT. The Microneedle Photodynamic Therapy II (MNPDT-II) study was a randomized, single-blinded, split-face controlled, 2-arm clinical trial. Thirty-three participants with AK on the face were recruited in a university dermatology outpatient clinic from 2015 to 2016, and 32 participants completed the study. Participants were randomized into 2 incubations arms, either 10-minute or 20-minute aminolevulinic acid (ALA) incubation times, after pretreatment with a microneedle roller (200 um) vs a sham roller. They were blinded to the laterality of microneedle and sham roller assignments. After incubation, they were exposed to blue light (Blu-U, Dusa Pharmaceuticals) for 1000 seconds for a total fluence of 10 J/cm2. The primary outcome was to quantitatively measure AK resolution, and the secondary outcome was to assess pain associated with microneedle pretreatment. Thirty-three in...Continue Reading

Citations

Oct 7, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·T SteebM V Heppt
Jan 17, 2019·The Journal of Dermatological Treatment·Khoa Nguyen, Amor Khachemoune
Sep 3, 2019·Current Dermatology Reports·Alisen HuangJared Jagdeo
Jul 19, 2020·Dermatology and Therapy·Jaime Piquero-CasalsJosé Luis López-Estebaranz
Sep 28, 2020·Journal of Biophotonics·Michelle Barreto RequenaVanderlei Salvador Bagnato
Nov 25, 2020·Pharmaceutics·Seung-Yeon JeongSong-Yi Kim
Dec 29, 2020·International Journal of Pharmaceutics·Mathilde ChampeauLaurent Mortier
Mar 3, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Miguel Angel Lopez-RamirezJoseph Wang
Mar 10, 2021·Journal of Pharmaceutical Investigation·Jae Hwan Jung, Sung Giu Jin
Jul 4, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Defu ZhiRyan F Donnelly
Apr 7, 2021·Journal of the American Academy of Dermatology·Daniel B EisenTodd E Schlesinger
Jul 12, 2019·Journal of Photochemistry and Photobiology. B, Biology·Mathilde ChampeauSerge Mordon

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