Effect of experimental elevation of free fatty acids on insulin secretion and insulin sensitivity in healthy carriers of the Pro12Ala polymorphism of the peroxisome proliferator--activated receptor-gamma2 gene

Diabetes
Norbert StefanMichael Stumvoll

Abstract

The transcription of many genes involved in lipid metabolism is regulated by the peroxisome proliferator-activated receptor-gamma (PPAR-gamma). The Pro12Ala polymorphism in the PPAR-gamma2 gene has been associated with reduced transcriptional activity in vitro and increased insulin sensitivity in vivo. Although PPAR-gamma has been demonstrated in human beta-cells, it is unknown whether the Pro12Ala polymorphism plays a role in insulin secretion. Moreover, it is also unknown if and how the effect of free fatty acids (FFAs) on insulin secretion and insulin sensitivity is modulated by the presence of this polymorphism. We therefore performed hyperglycemic clamps (8 mmol/l, 140 min, 5 g arginine bolus at min 120) in 10 healthy subjects with the (X/Ala) polymorphism and in 10 subjects without the polymorphism (Pro/Pro) basally and after 5 h infusion of Intralipid plus heparin. FFA concentrations increased from 473 +/- 61 micromol/l to 1,732 +/- 163 micromol/l in the Pro/Pro and from 372 +/- 46 micromol/l to 1,630 +/- 96 micromol/l in the X/Ala group (P = 0.68). Basally, neither insulin sensitivity nor insulin secretion were significantly different between the two groups. During infusion of Intralipid, first-phase insulin secretion r...Continue Reading

References

Oct 1, 1984·The Journal of Clinical Investigation·W K WardD Porte
Jun 1, 1994·The Journal of Clinical Investigation·G BodenL Rossetti
Jun 3, 1998·Diabetic Medicine : a Journal of the British Diabetic Association·G Paolisso, B V Howard
Mar 4, 1999·Diabetologia·J D McGarry, R L Dobbins
Aug 14, 1999·Diabetologia·J Auwerx

❮ Previous
Next ❯

Citations

Dec 18, 2001·Diabetes/metabolism Research and Reviews·B NazlielB Koçer
Dec 14, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Peter WeyrichAndreas Fritsche
Mar 20, 2003·Current Diabetes Reports·Francesco S Celi, Alan R Shuldiner
Jun 12, 2003·Metabolism: Clinical and Experimental·Otto TschritterMichael Stumvoll
Jun 12, 2003·Metabolism: Clinical and Experimental·Claus ThamerHans Häring
Oct 29, 2003·Diabetes Research and Clinical Practice·Maciej T MaleckiJacek Sieradzki
Mar 20, 2002·Domestic Animal Endocrinology·Karen L HouseknechtPamela J Steele
Jul 18, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S ZraikaS Andrikopoulos
Jun 11, 2002·Annual Review of Nutrition·Frédéric Picard, Johan Auwerx
Apr 25, 2009·PPAR Research·Weimin He
Jan 7, 2005·Nutrition & Metabolism·Zahra Fatehi-Hassanabad, Catherine B Chan
Jul 23, 2005·International Journal of Clinical Practice. Supplement·R A DeFronzo
Jul 30, 2002·Diabetes·Michael Stumvoll, Hans Häring
Mar 29, 2003·Diabetes Care·Otto TschritterMichael Stumvoll
Jun 28, 2016·Diabetologia·Hans-Ulrich Häring
Jul 24, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·S PrudenteV Trischitta
Apr 23, 2002·Pharmacogenomics·Carsten OttoBurkhard Göke
Sep 16, 2004·European Journal of Human Genetics : EJHG·Raffaella BuzzettiUmberto Di Mario
Jan 6, 2018·Upsala Journal of Medical Sciences·Prasad G KambleErik Ingelsson
Jul 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Mark I McCarthy, Philippe Froguel
Dec 18, 2002·American Journal of Physiology. Endocrinology and Metabolism·Elisabeth QvigstadValdemar E Grill
Oct 26, 2018·Circulation. Genomic and Precision Medicine·Paul W Franks, Nicholas J Timpson
Aug 9, 2007·Arquivos brasileiros de endocrinologia e metabologia·Vladimir TavaresRosario D Crespo Hirata

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.