PMID: 11604062Oct 18, 2001Paper

Effect of exposure to 900 MHz radiofrequency radiation on intrachromosomal recombination in pKZ1 mice

Radiation Research
P J SykesAlexander A Morley

Abstract

Radiofrequency (RF) radiation emitted from mobile phones is not considered to be directly genotoxic, but it may have downstream effects on cellular DNA. We studied the effect of 4 W/kg pulsed 900 MHz RF radiation on somatic intrachromosomal recombination in the spleen in the pKZ1 recombination mutagenesis model. Somatic intrachromosomal recombination inversion events were detected in spleen tissue of pKZ1 mice by histochemical staining for E. coli beta-galactosidase protein in cells in which the lacZ transgene has undergone an inversion event. pKZ1 mice were exposed daily for 30 min to plane-wave fields of 900 MHz with a pulse repetition frequency of 217 Hz and a pulse width of 0.6 ms for 1, 5 or 25 days. Three days after the last exposure, spleen sections were screened for DNA inversion events. There was no significant difference between the control and treated groups in the 1- and 5-day exposure groups, but there was a significant reduction in inversions below the spontaneous frequency in the 25-day exposure group. This observation suggests that exposure to RF radiation can lead to a perturbation in recombination frequency which may have implications for recombination repair of DNA. The biological significance of a reduction ...Continue Reading

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Citations

Aug 29, 2012·Cell Biochemistry and Biophysics·Kavindra Kumar KesariJitendra Behari
Jul 11, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Daniel KrewskiDonald F Weaver
Jul 16, 2005·International Journal of Radiation Biology·J E MoulderJ P McNamee
Jul 14, 2007·Fertility and Sterility·Ji-Geng YanHani S Matloub
May 25, 2005·International Journal of Andrology·R J AitkenB V King
Feb 22, 2012·International Journal of Radiation Biology·Semra Tepe Çam, Nesrin Seyhan
Sep 28, 2004·Radiation Research·Antony M HookerPamela J Sykes
Jul 24, 2008·Dose-response : a Publication of International Hormesis Society·P J SykesA M Hooker
Oct 20, 2010·Mutation Research·L VerschaeveZ Xu
Mar 17, 2009·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Hugo W Ruediger
Mar 20, 2003·Radiation Research· VijayalaxmiLarry E Anderson
Jul 13, 2019·Journal of Environmental Health Science & Engineering·Shikha ChandelRavinder Kumar Kohli
Sep 1, 2004·DNA Repair·Carrie A Hendricks, Bevin P Engelward

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