Effect of exposure to light-at-night on life span and spontaneous carcinogenesis in female CBA mice

International Journal of Cancer. Journal International Du Cancer
V N AnisimovAnatoly I Yashin

Abstract

The effect of constant illumination on the development of spontaneous tumors in female CBA mice was investigated. Fifty female CBA mice starting from the age of 2 months were kept under standard light/dark regimen (12 hr light:12 hr dark; LD) and 50 CBA mice of similar age were kept under constant illumination (24 hr a day, 2,500 Lux, LL). Exposure to the LL regimen decreased food consumption but did not influence body weight, significantly accelerated age-related disturbances in estrous function, and was followed by a significant increase in spontaneous tumor incidence in female CBA mice. Tumor incidence as well as the number of total or malignant tumors was significantly increased in the LL group compared to the LD group (p < 0.001). The incidence of lung adenocarcinomas, leukemias and hepatocarcinomas was 7/50; 6/50 and 4/50 in the LL group and 1/50; 0/50 and 0/50 in the LD group. Mice from the LL groups had shorter life spans then those from the LD group. The data demonstrate, for the first time, that exposure to constant illumination was followed by increases in the incidence of spontaneous lung carcinoma, leukemias and hepatocarcinoma in female CBA mice.

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Citations

Aug 2, 2005·Bioelectromagnetics·Denis L Henshaw, Russel J Reiter
Oct 1, 2005·Nature Reviews. Cancer·Vladimir N AnisimovAnatoly I Yashin
May 21, 2014·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·A Ahamed BashaK Ramesh Rao
Jul 22, 2015·Current Biology : CB·Kirsten C G Van DyckeGijsbertus T J van der Horst
Sep 7, 2007·Journal of Pineal Research·Kristen J Navara, Randy J Nelson
Mar 8, 2014·CA: a Cancer Journal for Clinicians·Richard G StevensMario E Motta
Jan 3, 2006·Physiology & Behavior·Stephanie L BakerCatherine Bielajew
Jun 14, 2005·Cancer Letters·Samuel CosEmilio J Sánchez-Barceló
Mar 11, 2015·Journal of Pineal Research·Zhenlong XinGang Ji
Mar 29, 2008·Mechanisms of Ageing and Development·Vladimir N Anisimov
Mar 18, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Therésa M JonesMark P Green
Feb 3, 2015·Frontiers in Genetics·Victoria P BelancioS Michal Jazwinski
Jul 7, 2007·Stress : the International Journal on the Biology of Stress·S Baker, C Bielajew
Nov 7, 2017·British Journal of Pharmacology·Regina P MarkusMarina Marçola
Oct 30, 2019·Chronobiology International·Mikhail F BorisenkovElvira E Symaniuk
Jun 6, 2017·Aging and Disease·Alexey MoskalevMikhail Shaposhnikov
May 9, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lara G SigurdardottirSteven W Lockley
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Oct 23, 2020·Clocks & Sleep·Monica N MorganKristina M Cook
Dec 12, 2020·International Journal of Molecular Sciences·William H WalkerA Courtney DeVries

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