Effect of extended CT perfusion acquisition time on ischemic core and penumbra volume estimation in patients with acute ischemic stroke due to a large vessel occlusion

PloS One
Jordi BorstMR CLEAN investigators

Abstract

It has been suggested that CT Perfusion acquisition times <60 seconds are too short to capture the complete in and out-wash of contrast in the tissue, resulting in incomplete time attenuation curves. Yet, these short acquisitions times are not uncommon in clinical practice. The purpose of this study was to investigate the occurrence of time attenuation curve truncation in 48 seconds CT Perfusion acquisition and to quantify its effect on ischemic core and penumbra estimation in patients with acute ischemic stroke due to a proximal intracranial arterial occlusion of the anterior circulation. We analyzed CT Perfusion data with 48 seconds and extended acquisition times, assuring full time attenuation curves, of 36 patients. Time attenuation curves were classified as complete or truncated. Ischemic core and penumbra volumes resulting from both data sets were compared by median paired differences and interquartile ranges. Controlled experiments were performed using a digital CT Perfusion phantom to investigate the effect of time attenuation curve truncation on ischemic core and penumbra estimation. In 48 seconds acquisition data, truncation was observed in 24 (67%) cases for the time attenuation curves in the ischemic core, in 2 case...Continue Reading

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Citations

Mar 19, 2016·Expert Review of Neurotherapeutics·Georgios TsivgoulisAndrei V Alexandrov
Jul 22, 2015·Clinical Neurology and Neurosurgery·Pieter C VosJan Willem Dankbaar
Nov 5, 2015·PloS One·Ralph R E G GeuskensUNKNOWN MR CLEAN trial investigators(www.mrclean-trial.org)
Nov 7, 2015·Stroke; a Journal of Cerebral Circulation·Jordi BorstUNKNOWN MR CLEAN investigators
Nov 30, 2016·Stroke; a Journal of Cerebral Circulation·Aimen S KasasbehMaarten G Lansberg
Jun 17, 2019·Journal of Neurointerventional Surgery·Miou S KoopmanUNKNOWN MR CLEAN Trial Investigators
Oct 8, 2019·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Christopher A PotterMichael H Lev
Jul 15, 2016·Journal of Medical Imaging·Edwin BenninkHugo W A M de Jong
Aug 24, 2021·Clinical Hemorheology and Microcirculation·Cornelius KruschePhilipp Wiggermann

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Philips software
Philips
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