PMID: 6965988Jan 1, 1980Paper

Effect of external cation and anion substitutions on sodium transport in isolated frog skin

The Journal of Membrane Biology
T U Biber, T L Mullen

Abstract

Effects of changes in external ionic strength, external cation and/or anion substitution on transepithelial influx and efflux of sodium, short-circuit current and on transepithelial potential difference and resistance were studied in isolated frog skin. Active transport of Na was found to be highly dependent on both anionic and cationic composition of external medium. Relative abilities of external monovalent cations to inhibit active Na transport were H greater than Li greater than K greater than Rb greater than Cs greater than choline. Relative abilities of external monovalent anions to stimulate active Na transport were I greater than Br greater than Cl. Sequences of anion interaction and of resistance changes suggest that anionic stimulation of Na transport is not due to electrical coupling across outer cell membrane. The ability of different anions and cations to alter Na transport suggests that externally located charged groups act as important barriers or filters to ion movement. In addition, the experiments suggest that an increase in ionic strength of external medium has an effect on active transport of Na, a finding that indicates interference of surface charges with Na entry. Directional changes in efflux of Na due t...Continue Reading

References

Oct 1, 1976·The American Journal of Physiology·T U Biber, T L Mullen
Dec 15, 1977·The Journal of Membrane Biology·W Nagel
Jan 1, 1977·The American Journal of Physiology·T U Biber, T L Mullen
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Citations

Jan 1, 1982·The Journal of Membrane Biology·L G Palmer
Jan 1, 1980·The Journal of Membrane Biology·T U BiberJ A DeSimone
Aug 21, 1980·The Journal of Membrane Biology·T U BiberT L Mullen
Jun 15, 1980·The Journal of Membrane Biology·T U BiberT L Mullen
Jan 1, 1982·The Journal of Membrane Biology·P M Hughes, A D Macknight
Oct 1, 1986·Acta Physiologica Scandinavica·A F Harck, E H Larsen

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