Effect of extra-amniotic Foley's catheter and vaginal misoprostol versus vaginal misoprostol alone on cervical ripening and induction of labor in Kenya, a randomized controlled trial

BMC Pregnancy and Childbirth
Alfred OsotiInnocent Maranga

Abstract

The safest, most effective and fastest combined approaches to induction of labor is unknown. In an open-label randomized clinical trial we evaluated the efficacy of combination of extra-amniotic Foley's catheter and vaginal misoprostol compared to vaginal misoprostol alone for cervical ripening and induction of labor on the incidence of failed induction, induction-to-delivery interval and adverse maternal and perinatal outcomes. Pregnant women at gestational age of 28 weeks or greater admitted at Kenyatta National Hospital, Kenya for induction of labor were enrolled then randomized to either a combination of extra-amniotic Foley's catheter inflated by 30 cm3 of normal saline and 25 micrograms of vaginal misoprostol or 25 micrograms of vaginal misoprostol alone. Women underwent 6 hourly reviews and additional misoprostol inserted if required. The primary outcome was incidence of failed induction. Secondary outcomes were induction-to-delivery interval and adverse maternal and perinatal outcomes. We conducted an intent-to-treat analysis and compared means or medians using t-test or Wilcoxon rank, proportions using Chi-square or Fishers test as appropriate. Induction-to-delivery interval were compared using the log-rank test. P-val...Continue Reading

References

Oct 26, 2005·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M KashanianM Fekrat
Aug 4, 2006·Clinical Obstetrics and Gynecology·Monique G Lin, Dwight J Rouse
Jul 23, 2009·Obstetrics and Gynecology·UNKNOWN ACOG Committee on Practice Bulletins -- Obstetrics

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Citations

Feb 12, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Lía OrnatUNKNOWN Health Outcomes and Systematic Analyses (HOUSSAY) Research Group
Oct 18, 2019·The Cochrane Database of Systematic Reviews·Marieke Dt de VaanMichel Boulvain

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BETA
cesarean sections
cesarean section

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SPSS®

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