PMID: 1473790Nov 1, 1992Paper

Effect of extraneous supplementation of ascorbic acid on the bio-disposition of benzanthrone in guinea pigs

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
K GargG B Singh

Abstract

The bio-elimination and organ retention of orally administered [14C]benzanthrone, an anthraquinone dye intermediate, were determined in control and ascorbic acid-supplemented guinea pigs. Urinary excretion of benzanthrone in control and ascorbic acid-treated animals during 96 hr was 27.9 and 30.5%, respectively, with peak elimination at 48 hr. Faecal elimination in control and supplemented animals during 96 hr was 24.5 and 38.8%, respectively, with a peak at 48 hr. The organ retention of radiolabelled benzanthrone at the end of 96 hr was of the order of 39% in control animals (gastro-intestinal tract 16%; liver 22%; testis 1.2%); ascorbic acid supplementation reduced benzanthrone retention to 19.5% (gastro-intestinal tract 12.7%; liver 6.8%). Overall, pretreatment of guinea pigs with ascorbic acid caused a 32% enhancement in the clearance of radiolabelled benzanthrone through the urine and faeces, while organ retention was reduced by about 50%. A prophylactic dose of ascorbic acid may prevent benzanthrone-induced toxic symptoms in exposed workers.

References

Apr 15, 1977·Biochemical Pharmacology·L E RikansV G Zannoni
Dec 1, 1976·Environmental Research·G B Singh, S K Khanna
Jun 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K GargG B Singh
Sep 1, 1990·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·L P SrivastavaP C Joshi
Jun 30, 1986·Toxicology and Applied Pharmacology·R L SusickV G Zannoni
Nov 15, 1974·Biochemical Pharmacology·P H Sato, V G Zannoni
Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·J J KammJ J Burns
Jun 15, 1973·Experientia·G B Singh, V N Tripathi
Jan 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·A CardesaP Shubik
Jan 1, 1984·Industrial Health·A JoshiC R Krishna Murti
Nov 1, 1983·Environmental Science & Technology·T Ramdahl

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Citations

Jul 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·N DwivediS K Khanna

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