PMID: 20644331Jul 21, 2010Paper

Effect of ezetimibe monotherapy on lipid metabolism and arterial stiffness assessed by cardio-ankle vascular index in type 2 diabetic patients

Journal of Atherosclerosis and Thrombosis
Yoh MiyashitaKohji Shirai

Abstract

High cholesterol absorption in the small intestine has been proposed to be a risk factor of atherosclerosis. In this study, we evaluated the effect of ezetimibe monotherapy on arterial stiffness in type 2 diabetic patients. Forty type 2 diabetes mellitus patients with high serum low-density lipoprotein cholesterol (LDL-C) were enrolled and treated with ezetimibe 10 mg/day for 6 months. HbA1c, serum lipids, remnant-like particle-cholesterol (RLP-C), serum lipoprotein lipase mass (LPL mass) and the cardio-ankle vascular index (CAVI) were measured before and after ezetimibe treatment. After 6 months of ezetimibe treatment, significant decreases in LDL-C, RLP-C and CAVI were observed. In the group that achieved the LDL-C goal of <120 mg/dL after 6 months of ezetimibe treatment, the pretreatment CAVI was markedly high, and CAVI decreased significantly after ezetimibe treatment. In type 2 diabetic patients, ezetimibe monotherapy may have the potential to ameliorate arterial stiffness in addition to lowering LDL-C and RLP-C.

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Citations

Jun 2, 2011·Journal of Atherosclerosis and Thrombosis·Kohji ShiraiMasanobu Takata
Feb 18, 2014·Internal Medicine·Tatsuyori MoritaIchiro Shiojima
Dec 4, 2010·Diabetes & Metabolism·P Valensi, S Picard
Oct 26, 2011·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Kazuhiko KotaniNobuyuki Taniguchi
Jan 16, 2018·Journal of Atherosclerosis and Thrombosis·Daiji NagayamaIchiro Tatsuno
Jun 5, 2012·Journal of Atherosclerosis and Thrombosis·Vladimir SoskaTomoyuki Yambe
Dec 1, 2012·Journal of Atherosclerosis and Thrombosis·Kenichiro KinouchiHiroshi Itoh
Jul 26, 2019·Expert Opinion on Pharmacotherapy·Niki KatsikiMaciej Banach
Jan 22, 2019·Current Vascular Pharmacology·Andromachi ReklouVasilios Athyros
Mar 6, 2013·Journal of Atherosclerosis and Thrombosis·Vladimir SoskaTomas Freiberger
Jan 26, 2011·The Tohoku Journal of Experimental Medicine·Hisashi MasugataFuminori Goda
Oct 12, 2016·Journal of Atherosclerosis and Thrombosis·Naohisa TomosugiYasuo Sakai
Oct 5, 2021·Pacing and Clinical Electrophysiology : PACE·Masaya ShinoharaTakanori Ikeda

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