Effect of ezetimibe on the in vivo kinetics of apoB-48 and apoB-100 in men with primary hypercholesterolemia

Arteriosclerosis, Thrombosis, and Vascular Biology
André J TremblayPatrick Couture

Abstract

To examine the impact of ezetimibe, a selective inhibitor of intestinal cholesterol absorption, on the in vivo kinetics of apolipoproteins (apo) B-48 and B-100 in humans. Kinetics of triglyceride-rich lipoprotein (TRL) apoB-48 and very-low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), and low-density lipoprotein (LDL) apoB-100 labeled with a stable isotope were assessed at baseline and at the end of 8 weeks of treatment with 10 mg/d of ezetimibe in 8 men with moderate primary hypercholesterolemia. Data were fit to a multicompartmental model using SAAMII to calculate fractional catabolic rate (FCR) and production rate (PR). Ezetimibe significantly decreased total and LDL cholesterol concentrations by -14.5% and -22.0% (P=0.004), respectively, with no significant change in plasma triglyceride and high-density lipoprotein (HDL) cholesterol levels. Ezetimibe had no significant effect on TRL apoB-48 kinetics and pool size (PS). However, VLDL and IDL apoB-100 FCRs were significantly increased (+31.2%, P=0.02 and +20.8%, P=0.04, respectively) with a concomitant elevation of VLDL apoB-100 PR (+20.9%, P=0.04). Furthermore, LDL apoB-100 PS was significantly reduced by -23.2% (P=0.004), caused by a significant increa...Continue Reading

References

Mar 1, 1979·Metabolism: Clinical and Experimental·J L WitztumM A Dillingham
Jan 1, 1983·Annual Review of Nutrition·S M Grundy
Sep 11, 2001·Journal of Clinical Pharmacology·F EzzetV Batra
Oct 9, 2002·Circulation·Thomas SudhopKlaus von Bergmann
Dec 31, 2002·Journal of the American College of Cardiology·Michael H DavidsonEnrico P Veltri
Feb 15, 2003·The American Journal of Cardiology·Boris KerznerUNKNOWN Ezetimibe Study Group
Sep 1, 1955·The Journal of Clinical Investigation·R J HAVELJ H BRAGDON
Feb 21, 2004·Science·Scott W AltmannMichael P Graziano
May 18, 2004·The Journal of Clinical Investigation·Mitsuhiro WatanabeJohan Auwerx
Jun 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Margarita Garcia-CalvoNancy A Thornberry
Dec 1, 1918·Proceedings of the National Academy of Sciences of the United States of America·J A Harris, F G Benedict

❮ Previous
Next ❯

Citations

Mar 3, 2010·Bulletin of Mathematical Biology·Rajasekhar Ramakrishnan, Janak D Ramakrishnan
Apr 24, 2012·Journal of Lipid Research·Luke J EngelkingGuosheng Liang
Aug 20, 2008·Journal of Lipid Research·F Jeffrey FieldSatya N Mathur
Mar 24, 2009·Journal of Lipid Research·André J TremblayPatrick Couture
Apr 22, 2009·Journal of Lipid Research·Thomas SudhopDieter Lütjohann
Apr 12, 2008·Expert Review of Cardiovascular Therapy·Harold E BaysAndrew M Tershakovec
Oct 17, 2006·Expert Opinion on Investigational Drugs·John R Burnett, Murray W Huff
Jul 16, 2010·Expert Opinion on Pharmacotherapy·Dick C Chan, Gerald F Watts
May 24, 2007·Current Medical Research and Opinion·Mihalis KalogirouMoses Elisaf
Jul 28, 2016·Diabetes, Obesity & Metabolism·Jean-Philippe Drouin-ChartierPatrick Couture
Jul 26, 2008·Atherosclerosis. Supplements·Joanne HsiehKhosrow Adeli
Nov 30, 2006·Journal of Lipid Research·Dawn E TelfordMurray W Huff
May 29, 2007·Journal of Lipid Research·Stefania Lamon-FavaErnst J Schaefer
Feb 12, 2010·Journal of Cardiovascular Pharmacology and Therapeutics·Ae-Young HerSang-Hak Lee
Sep 24, 2015·Nutrients·Helena Gylling, Piia Simonen
May 8, 2018·Clinical Pharmacology and Therapeutics·Benoit J ArsenaultRishi Puri
Jun 28, 2018·Journal of Lipid Research·Jean-Philippe Drouin-ChartierPatrick Couture
Sep 16, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Murray W HuffRobert A Hegele
Aug 1, 2008·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S Kidambi, S B Patel
Feb 22, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mark NaplesKhosrow Adeli
Apr 11, 2008·Clinical Science·Esther M M OoiGerald F Watts
Nov 22, 2011·Current Opinion in Lipidology·Harry R DavisThomas Musliner
Apr 4, 2014·The Journal of Clinical Endocrinology and Metabolism·Bruno VergèsRémy Burcelin
Jun 23, 2011·American Journal of Physiology. Endocrinology and Metabolism·Changting XiaoGary F Lewis
Apr 16, 2020·Diabetology & Metabolic Syndrome·Catherine LalandeAlain Veilleux
Jul 22, 2008·Metabolism: Clinical and Experimental·Rajasekhar Ramakrishnan, Janak D Ramakrishnan
Jun 6, 2009·Pharmacology & Therapeutics·Gerald F WattsDick C Chan
Feb 16, 2010·Pharmacology & Therapeutics·M John ChapmanPhilippe Giral

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.