Effect of fat cell size, restrictive diet and diabetes on lipoprotein lipase release by human adipose tissue

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
B Guy-Grand, B Bigorie


The lipoprotein lipase activity (LPLA) eluted from human adipose tissue was measured after percutaneous biopsy in the fasting state. A positive and significant correlation was found between LPLA per 10(6) cells or per cell surface unit and cell volume in 27 normal and obese subjects in weight balance and on maintenance diet. Such a correlation was also found in 13 diabetic subjects before treatment. In 11 obese subjects subjected to a restricted diet, LPLA dropped dramatically without a significant change in cell size, blunting the cell size effect. In diabetic subjects the LPLA per cell was significantly lower than in nondiabetic people with similar adipose cell volume.


Nov 1, 1979·Metabolism: Clinical and Experimental·A GoldbergW R Hazzard
May 1, 1981·The Journal of Clinical Investigation·R S Schwartz, J D Brunzell
Oct 1, 1982·The Journal of Clinical Investigation·J S ReitmanE A Nikkila
Oct 1, 1987·The Journal of Clinical Investigation·R H Eckel, T J Yost
Jan 1, 1989·Annals of the New York Academy of Sciences·M Cabanac
Mar 1, 1980·Metabolism: Clinical and Experimental·A GoldbergJ D Brunzell
Sep 1, 1978·Metabolism: Clinical and Experimental·J D BrunzellE L Bierman
Jul 1, 1987·Metabolism: Clinical and Experimental·M R Taskinen, E A Nikkila
Dec 1, 1981·European Journal of Clinical Investigation·R SörbrisP Nilsson-Ehle
Apr 1, 1987·Diabetes/metabolism Reviews·M R Taskinen
Jun 14, 2005·Biochimica Et Biophysica Acta·Lise MadsenKarsten Kristiansen
Apr 1, 1978·European Journal of Clinical Investigation·H LithellB Vessby
Jul 1, 1987·The British Journal of Nutrition·L A SmolinJ A Brasel
Mar 1, 1985·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·Y A KesaniemiS M Grundy
Oct 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·B J NicklasA Goldberg
Jan 1, 1977·Acta Medica Scandinavica·M R Taskinen, E A Nikkila
Oct 1, 1994·The American Journal of Physiology·A BoivinY Deshaies

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