PMID: 9186759May 23, 1997Paper

Effect of fat intake on energy balance

Annals of the New York Academy of Sciences
P A Tataranni, E Ravussin

Abstract

Most epidemiological studies indicate that obesity is more prevalent in populations consuming high fat diets. Furthermore, changes from a traditional to a westernized life style, characterized by a high-fat diet and decreased physical activity, result in dramatic increases in the prevalence and incidence of obesity in Native Americans, Pacific Islanders, and African populations. A possible explanation for the epidemic of obesity in response to high-fat intake can be found in the "oxidative hierarchy" that regulates macronutrient balance in the human body. Although carbohydrate and protein balances seem promptly regulated, fat balance is not. Short and midterm studies show that, unlike carbohydrate and protein intake, fat intake does not promote fat oxidation. Thus, "excess" fat intake results in fat deposition. As fat mass increases, so does fat oxidation, and a new equilibrium is reached when fat oxidation matches fat intake. However, there are large interindividual differences in this compensatory response to increased fat intake. Substrate oxidation is a familial trait, and individuals with a low fat-to-carbohydrate oxidation ratio are more prone to develop obesity than those with a high fat-to-carbohydrate oxidation ratio. ...Continue Reading

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Citations

Jan 4, 2012·Annals of the New York Academy of Sciences·Julien Delezie, Etienne Challet
Feb 5, 2003·The American Journal of Medicine·Walter C Willett, Rudolph L Leibel
May 28, 1998·The Journal of the American Dental Association·I D Mandel
Nov 6, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S W YauM A Sabin
Sep 21, 2013·Adipocyte·Gunnhildur Asta TraustadottirDitte C Andersen
Nov 6, 2013·Critical Reviews in Food Science and Nutrition·Balasubramanian GanesanDonald J McMahon
Feb 19, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·I KunzA M Sharma
Sep 19, 2001·Pharmacotherapy·D R Guay
Jun 16, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Geltrude MingroneEleuterio Ferrannini
Aug 3, 2000·Journal of Perinatal Medicine·A KurjakM Stanojevic
Dec 10, 2016·Frontiers in Nutrition·Erin D GilesPaul S MacLean
Oct 26, 2002·The American Journal of Clinical Nutrition·Sharon S ElliottPeter J Havel

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