Effect of fatty acids on endothelium-dependent relaxation in the rabbit aorta

Clinical Science
Indika EdirisingheC Tissa Kappagoda

Abstract

The metabolic syndrome, Type II (non-insulin-dependent) diabetes and obesity are associated with endothelial dysfunction and increased plasma concentrations of NEFAs (non-esterified fatty acids; free fatty acids). The present study was undertaken to define the inhibitory effects of saturated NEFAs on EDR (endothelium-dependent relaxation). Experiments were performed in rings of rabbit aorta to establish (i) dose-response relationships, (ii) the effect of chain length, (iii) the effect of the presence of double bonds, (iv) reversibility and time course of inhibition, and (v) the effect on nitric oxide production. Aortic rings were incubated (1 h) with NEFA-albumin complexes derived from lauric (C(12:0)), myristic (C(14:0)), palmitic (C(16:0)), stearic (C(18:0)) and linolenic (C(18:3)) acids. EDR induced by acetylcholine (0.1-10 mumol/l) was measured after pre-contraction with noradrenaline. Inhibition of EDR was dose-dependent (0.5-2 mmol/l NEFA), and the greatest inhibition (51%) was observed with stearic acid (2 mmol/l). Lauric acid had the smallest inhibitory effect. The inhibitory effects were always reversible and were evident after 15 min of incubation. Linolenic acid caused a significantly lower inhibition of EDR than ste...Continue Reading

References

Feb 1, 1987·Circulation Research·L JayakodyT Kappagoda
Mar 1, 1985·The Journal of Clinical Investigation·M ModanZ Fuchs
Mar 1, 1996·Journal of the American College of Cardiology·S B WilliamsM A Creager
Sep 1, 1997·The Journal of Clinical Investigation·H O SteinbergA D Baron
Jun 22, 2002·Annals of the New York Academy of Sciences·Michael G EspeyDavid A Wink
Apr 30, 2003·Antioxidants & Redox Signaling·Victor E EsenabhaluWolfgang F Graier
Jul 25, 2003·European Journal of Clinical Nutrition·N DierckxB Manuel-y-Keenoy
Jul 16, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Hasan ErdoganOzge Ardicoglu
Sep 16, 2004·Clinical Science·Christopher A R SainsburyJohn R Petrie
Mar 22, 2005·European Journal of Pharmacology·Milad S BitarFahd Al-Mulla
Aug 24, 2005·Journal of Internal Medicine·C VitaleG M C Rosano

❮ Previous
Next ❯

Citations

Dec 23, 2011·Basic Research in Cardiology·Hanrui ZhangCuihua Zhang
Jan 8, 2013·Reviews in Endocrine & Metabolic Disorders·J David Symons, E Dale Abel
Jul 24, 2012·Endocrine·Sazan RasulAlexandra Kautzky-Willer
Oct 11, 2012·The British Journal of Nutrition·Ana Rodriguez-MateosJunji Terao
Aug 15, 2009·Journal of the American College of Cardiology·Oliver J RiderStefan Neubauer
Jun 1, 2014·Free Radical Biology & Medicine·Brian E Sansbury, Bradford G Hill
Oct 9, 2012·International Journal of Cardiology·Oliver J RiderStefan Neubauer
Mar 6, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Natacha SlobodaAthanase Benetos
Jan 6, 2017·Basic & Clinical Pharmacology & Toxicology·Naiane Ferraz Bandeira AlvesValdir de Andrade Braga
Apr 12, 2012·Circulation. Cardiovascular Imaging·Oliver J RiderStefan Neubauer
Mar 20, 2009·Expert Review of Cardiovascular Therapy·Yoonjung ParkCuihua Zhang
Sep 23, 2008·The Journal of Nutrition·Sarah E E BerryThomas A B Sanders
Dec 17, 2019·Dose-response : a Publication of International Hormesis Society·Soo Hee LeeJu-Tae Sohn
Oct 12, 2007·Clinical Science·Indika EdirisingheC Tissa Kappagoda
Jun 27, 2013·American Journal of Physiology. Endocrinology and Metabolism·Sonia M NajjarSüleyman Ergün

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.