PMID: 9537065Jan 1, 1980Paper

Effect of Fc-receptor modulation on mumps-virus-dependent lymphocyte-mediated cytotoxicity in vitro

Scandinavian Journal of Immunology
B HärfastP Perlmann

Abstract

The natural cytotoxicity of peripheral blood lymphocytes (PBL) from normal human donors to a variety of tissue culture target cells increases upon brief exposure of lymphocytes to mumps virus. The effector cells operative in this system have Fc receptors for IgG (FcR), since cytotoxicity was abolished when FcR+ cells were removed by passage of the lymphocyte over immune-complex columns. When PBL were treated with immune complexes for 16 h at 37 degrees C, their FcR activity was sharply decreased (modulation), as indicated by a significantly reduced capacity of the treated cells to display antibody-dependent cytotoxicity (ADCC). Modulation had variable effects on natural cytotoxicity. In contrast, the virus-dependent cytotoxicity above the natural cytotoxicity remained essentially unchanged, indicating that a functionally intact FcR is not required in this system for carrying out cytolysis.

References

Oct 1, 1977·Journal of the National Cancer Institute·Y Koide, M Takasugi
Jul 1, 1977·Cancer·P PerlmannG R Pape
Apr 1, 1977·Infection and Immunity·A Moller-LarsenS Haahr
Jan 1, 1978·Advances in Cancer Research·R B Herberman, H T Holden
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May 1, 1973·International Journal of Cancer. Journal International Du Cancer·J BubeníkJ Donner

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Citations

Apr 1, 1985·Scandinavian Journal of Immunology·A R AlsheikhlyP Perlmann
Nov 1, 1984·Scandinavian Journal of Immunology·A R AlsheikhlyP Perlmann
Apr 1, 1985·Scandinavian Journal of Immunology·A R AlsheikhlyP Perlmann

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