PMID: 9546944Jan 1, 1997Paper

Effect of felodipine on regional blood supply and collateral vascular resistance in patients with peripheral arterial occlusive disease

Vascular Medicine
Y LiuJ M Steinacker

Abstract

This double-blinded, randomized, placebo-controlled study was designed to investigate the acute effect of felodipine on regional blood supply and collateral vascular resistance in patients with peripheral arterial occlusive disease (PAOD). Thirty men with PAOD were treated with a single dose of 5 mg felodipine or placebo. Systolic blood pressure (SBP), Doppler ankle pressure (DAP), calf blood flow (CBF) by venous occlusion plethysmography and calf transcutaneous oxygen tension (tcpO2) were measured during a cycle ergometry. Felodipine reduced SBP significantly (from 149 to 136 mmHg, p < 0.05), while placebo did not. DAP increased slightly but not significantly in both groups. The pressure gradient between SBP and DAP fell significantly in the felodipine group (60 vs 39 mmHg, p < 0.01) but not in the placebo group (59 vs 56 mmHg). There was a trend for lower velocity in tcpO2 decrease during the stress test and higher velocity of tcpO2 increase during recovery from exercise in the felodipine group although the differences between both groups were not significant. In the felodipine group, CBF increased by 35.6% (p < 0.05) whereas it did not change in the placebo group. In conclusion, while lowering SBP, felodipine increased sligh...Continue Reading

References

Dec 1, 1979·Critical Care Medicine·K K TremperW C Shoemaker
Apr 1, 1990·Journal of Cardiovascular Pharmacology·L M CampbellS J Timerick
Jan 1, 1990·Journal of Cardiovascular Pharmacology·P Lund-Johansen
Jan 1, 1990·Journal of Cardiovascular Pharmacology·T O Morgan
Jan 15, 1992·The American Journal of Cardiology·Y S HwangE C Wong
Jan 1, 1991·Current Medical Research and Opinion·A WesterB Westberg
Apr 1, 1989·European Heart Journal·P H DunselmanK I Lie
Dec 1, 1988·British Journal of Clinical Pharmacology·D J SumnerH L Elliott
Jan 1, 1988·Journal of Applied Physiology·J M Steinacker, W Spittelmeister
Nov 1, 1987·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·K LingeG S Dowd
Jan 1, 1985·Drugs·E AgnerJ Trap-Jensen
Jan 1, 1985·Drugs·R J Hopkins, T W Hill
Jan 1, 1985·Drugs·B Ljung
May 1, 1970·Circulation·W B KannelD Shurtleff
Sep 1, 1983·The American Journal of Cardiology·J M DetryJ Renkin
Jan 1, 1983·European Journal of Clinical Pharmacology·G JohnssonI Hutton
Oct 1, 1981·Critical Care Medicine·D W Lübbers
Jul 1, 1993·Journal of Applied Physiology·H T Yang, R L Terjung
Jul 1, 1953·The Journal of Physiology·R J WHITNEY

❮ Previous
Next ❯

Citations

Jul 21, 2001·Journal of Human Hypertension·A MakinD G Beevers
Dec 7, 2013·The Cochrane Database of Systematic Reviews·Deirdre A Lane, Gregory Y H Lip
Dec 25, 2007·Progress in Cardiovascular Diseases·Mark L De Buyzere, Denis L Clement

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.