PMID: 42851Oct 1, 1979

Effect of fenfluramine administration on synaptosomal uptake of some neurotransmitters and on synaptosomal enzymes which metabolise GABA

Naunyn-Schmiedeberg's Archives of Pharmacology
J C KouyoumdjiianM F Belin

Abstract

Fenfluramine has been considered to deplete neuronal 5-hydroxytryptamine (5-HT). This compound is able to reduce the synaptosomal uptake of 5-HT and other neurotransmitters such as GABA and glutamic acid (Glu). The effects of fenfluramine on these three compounds considered as neurotransmitters are different. The inhibition is of competitive type for 5-HT and non-competitive for GABA and Glu. Concerning the enzymes involved in GABA synthesis and degradation, Fenfluramine increases Glutamic acid decarboxylase activity and decreases GABA-trasaminase activity in synaptosomes. Decreased synaptosomal GABA levels could be attributed to a lower uptake. An enzymatic regulating system may be responsible in restoring the GABA level. A similar mechanism concerning serotonin has been previously suggested (Costa et al., 1971).

References

Aug 1, 1995·Molecular Neurobiology·R I Westphalen, P R Dodd
Jan 1, 1986·Progress in Neurobiology·N E Rowland, J Carlton

Related Concepts

GAD1
Brain
Glutamate Decarboxylase
Neurohormones
Pondimin
Gamma-Aminobutyric Acid, Zinc Salt (2:1)
Synaptosomes
4-Aminobutyrate aminotransferase

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