Effect of fenofibrate on plasma apolipoprotein C-III levels: a systematic review and meta-analysis of randomised placebo-controlled trials

BMJ Open
A SahebkarStephen L Atkin

Abstract

This meta-analysis of randomised placebo-controlled clinical trials aimed to assess the effect of fenofibrate on apolipoprotein C-III (apo C-III), a key regulator of triglyceride metabolism. Randomised placebo-controlled trials investigating the impact of fenofibrate treatment on apo C-III levels were searched in PubMed-Medline, Scopus, Web of Science and Google Scholar databases from inception to 18 August 2017. Quantitative data synthesis was determined by a random-effects model and generic inverse variance method. Sensitivity analysis was conducted using the leave-one-out method. A weighted random-effects meta-regression was performed to evaluate glycaemic parameter confounders. Meta-analysis of 10 clinical trials involving 477 subjects showed fenofibrate therapy decreased apo C-III levels (weighted mean difference (WMD) -4.78 mg/dL, 95% CI -6.95 to -2.61, p<0.001; I266.87%). Subgroup analysis showed that fenofibrate reduced plasma apo C-III concentrations in subgroups of trials with treatment durations of either <12 weeks (WMD -4.50 mg/dL, p=0.001) or ≥12 weeks (WMD: -4.73 mg/dL, p=0.009) and doses of fenofibrate <200 mg/day (WMD -6.33 mg/dL, p<0.001) and >200 mg/day (p=0.006), with no significant difference between the sub...Continue Reading

References

Sep 11, 2003·Clinical Pharmacology and Therapeutics·Gloria Lena VegaScott M Grundy
Aug 25, 2004·Current Medical Research and Opinion·Teddy KosoglouEnrico P Veltri
Jun 27, 2006·Clinical Cardiology·Michael H DavidsonUNKNOWN TRIMS Investigators
Apr 26, 2008·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Emmanuelle JeanpierreDelphine Corseaux
Oct 30, 2008·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Jean-Charles FruchartUNKNOWN Residual Risk Reduction Initiative (R3I)
Nov 11, 2008·The New England Journal of Medicine·Paul M RidkerUNKNOWN JUPITER Study Group
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Nov 17, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Carlos O MendivilFrank M Sacks
Dec 17, 2009·Atherosclerosis·Ashish ShahJohn S Millar
Mar 23, 2011·Journal of Lipid Research·Frank M Sacks Editorial BoardJeffrey S Cohn Editorial Board
Aug 30, 2012·Journal of Lipid Research·Esther M M OoiP Hugh R Barrett
Jan 16, 2013·Current Pharmaceutical Design·Niki KatsikiManfredi Rizzo
Jan 1, 2014·Progress in Molecular Biology and Translational Science·Mahmoud Mansour
Jun 19, 2014·The New England Journal of Medicine·Jacy CrosbySekar Kathiresan
Jul 1, 2003·Current Therapeutic Research, Clinical and Experimental·Tsutomu Kazumi For The Fenofibrate Study Group
Dec 4, 2014·The New England Journal of Medicine·Daniel GaudetJoseph L Witztum
Jul 30, 2015·The New England Journal of Medicine·Daniel GaudetJohn J P Kastelein
Aug 1, 2015·Journal of Clinical Lipidology·Moritz C Wyler von BallmoosFrank M Sacks
Sep 20, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Giuseppe DerosaAmirhossein Sahebkar
Dec 15, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Amirhossein SahebkarUNKNOWN Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group
Dec 19, 2015·Physiological Research·M Vrablík, R Češka
Mar 31, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Amirhossein SahebkarSubash C Gupta
Apr 18, 2016·Metabolism: Clinical and Experimental·Amirhossein SahebkarJorge Joven

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