Effect of ferulic acid from Hibiscus mutabilis on filarial parasite Setaria cervi: molecular and biochemical approaches

Parasitology International
Prasanta SainiSanti P Sinha Babu

Abstract

In the reported work the in vitro activity of a methanolic extract of leaves of Hibiscus mutabilis (Malvaceae) against bovine Setaria cervi worms has been investigated. Bioassay-guided fractionation led to isolation of ferulic acid from ethyl acetate fraction. The crude extract and ferulic acid, the active molecule, showed significant microfilaricidal as well as macrofilaricidal activities against the microfilaria (L(1)) and adult of S. cervi by both a worm motility and MTT reduction assay. The findings thus provide a new lead for development of a filaricidal drug from natural products. To examine the possible mechanism of action of ferulic acid, the involvement of apoptosis in adult worms of S. cervi was investigated. We found extreme cellular disturbances in ferulic acid-treated adult worms characterized by chromatin condensation, in situ DNA fragmentation and nucleosomal DNA laddering. In this work we are reporting for the first time that ferulic acid exerts its antifilarial effect through induction of apoptosis and by downregulating and altering the level of some key antioxidants (GSH, GST and SOD) of the filarial nematode S. cervi. Our results have provided experimental evidence supporting that ferulic acid causes an incre...Continue Reading

References

Apr 1, 1987·Immunological Investigations·N A KaushalS Ghatak
Feb 1, 1989·International Journal for Parasitology·J C ComleyD C Jenkins
Jan 1, 1987·Free Radical Research Communications·R H SchirmerR L Krauth-Siegel
Oct 15, 1998·International Journal for Parasitology·M E SelkirkK Gounaris
May 30, 2001·Molecular and Biochemical Parasitology·K Henkle-Dührsen, A Kampkötter
Oct 16, 2001·Journal of Agricultural and Food Chemistry·H S LeeM K Kim
Jul 9, 2002·The Journal of Parasitology·R Rao, Gary J Well
Jan 28, 2004·Cell·Nika N Danial, Stanley J Korsmeyer
Apr 2, 2004·Cell·Junying Yuan, H Robert Horvitz
Oct 7, 2004·European Journal of Medicinal Chemistry·Balasubramanian NarasimhanAvinash Dhake
Oct 4, 2005·Cell Biology International·George V Z DedoussisNikolaos K Andrikopoulos
Jul 20, 2006·Journal of Agricultural and Food Chemistry·Bolleddula JayaprakasamMuraleedharan G Nair
Sep 4, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Li-Fang ZhengZhong-Li Liu
Jan 12, 2008·Journal of Clinical Biochemistry and Nutrition·Marimuthu SrinivasanVenugopal P Menon
May 23, 2009·Parasitology Research·Lorena Chiumiento, Fabrizio Bruschi
Nov 6, 2009·Annual Review of Genetics·Barbara Conradt
Jan 5, 2010·Free Radical Biology & Medicine·Magdalena L Circu, Tak Yee Aw
Mar 29, 2011·Experimental Parasitology·A NayakS P Sinha Babu
May 24, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Subburayan KarthikeyanRajendran Mahalakshmi
Feb 7, 2012·Experimental Parasitology·Jyoti GuptaShailja Misra-Bhattacharya
Feb 22, 2012·European Journal of Medicinal Chemistry·Koneni V SashidharaShailja Misra-Bhattacharya

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Citations

Jul 11, 2014·Parasitology International·Prasanta SainiSanti P Sinha Babu
Feb 20, 2016·Food and Environmental Virology·Doris H D'SouzaP Michael Davidson
Dec 3, 2014·Journal of Proteomics·Savitri TiwariSushma Rathaur
Dec 4, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Nazeh M Al-AbdS Sivanandam
Jul 6, 2015·Food and Environmental Virology·Snehal S JoshiDoris H D'Souza
Dec 3, 2014·Asian Pacific Journal of Tropical Medicine·Niladri MukherjeeSanti P Sinha Babu
Jul 16, 2016·The Korean Journal of Parasitology·Nazeh M Al-AbdMustafa Kassim
Dec 5, 2019·Current Drug Targets·Pone Kamdem Boniface, Ferreira Igne Elizabeth
Aug 15, 2018·Scientific Reports·Suprabhat MukherjeeSanti P Sinha Babu
Jul 1, 2017·Comprehensive Reviews in Food Science and Food Safety·Eliane de Oliveira Silva, Ronan Batista
Jul 4, 2020·Molecular and Biochemical Parasitology·Saptarshi RoyLarisha M Lyndem
Dec 24, 2017·Biochemical and Biophysical Research Communications·Mohit WadhawanSushma Rathaur
Feb 2, 2019·Bioresource Technology·Dyoni M OliveiraWanderley D Dos Santos

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