Effect of fetal anaemia on myocardial ischaemia-reperfusion injury and coronary vasoreactivity in adult sheep.

Acta Physiologica
Q YangL E Davis

Abstract

We investigated whether chronic fetal anaemia affects myocardial infarct in adulthood and elicits functional modifications in adult coronary vasoreactivity. Seven-month-old sheep that were made anaemic in utero and transfused to normal haematocrit before birth were studied. Infarct size was determined by tetrazolium after 1-h ischaemia (occlusion of the mid of left anterior descending artery) and 2-h reperfusion. The dose-response to vasoconstrictors and vasodilators was assessed in small resistance coronary arteries. There were no significant differences between the animals previously subjected to in utero anaemia and the control animals regarding the percentage infarct size and the area-at-risk to the left ventricle. The ventricular function (dP/dt) was preserved. The percentage infarct size of the area-at-risk (70.7 +/- 3.5%) was larger than that in the controls (49.8 +/- 4.5%) (P = 0.006). The vascular responses were not altered. Endothelium-dependent relaxation to bradykinin (96.0 +/- 2.6% vs. 98.8 +/- 1.0%) was not affected by PGI(2) inhibitor (94.6 +/- 2.6% vs. 98.5 +/- 1.0%) but significantly reduced by the inhibition of nitric oxide (NO) in both anaemic (P < 0.05) and control (P < 0.001) groups with a significant right...Continue Reading

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Citations

May 23, 2012·Vascular Pharmacology·Qin YangCheuk-Man Yu
Dec 1, 2011·Clinical and Experimental Pharmacology & Physiology·K J BottingJ L Morrison
Aug 27, 2014·BJOG : an International Journal of Obstetrics and Gynaecology·M WeltenVwv Jaddoe
Jul 16, 2015·Journal of Developmental Origins of Health and Disease·K L Thornburg
Nov 2, 2016·The Journal of Physiology·Sonnet S JonkerJonathan R Lindner
May 12, 2004·Critical Care Clinics·Paul C HébertLing Qun Hu
Sep 25, 2016·Archives of Disease in Childhood·Alexandra H WallaceJane E Harding
May 3, 2018·Physiological Reviews·Charles A DucsayLubo Zhang
May 24, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lowell DavisSonnet S Jonker
Feb 2, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Tara KaramlouKent L Thornburg

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