Effect of fibronectin on the adhesion of an established cell line to a surface reactive biomaterial

Journal of Biomedical Materials Research
T L SeitzN E Noonan


We have demonstrated that an established hamster cell line (NIL 8 M-2) will adhere to the bioceramic bioglass. The rate at which the NIL 8 M-2 cells assume a spread morphology on bioglass is density dependent and the morphology displayed by NIL 8 M-2 cells attached to bioglass is much more elongated than that displayed by NIL 8 M-2 cells attached to nonreactive glass. Precoating the bioglass with the plasma form of human fibronectin significantly reduces the density dependent nature of cell spreading. Coating the bioglass with fibronectin also reduces the time required for cell spreading and changes the morphology of the attached cells from an elongated to an extremely flattened shape. Our work raises the possibility that bone-implant adhesion might be improved by introducing molecules relevant to cell-substrate attachment into the biomaterial prior to implantation.


Aug 1, 1996·Journal of Biomedical Materials Research·E SöderlingA Yli-Urpo
Oct 23, 1997·Journal of Biomedical Materials Research·T KobayashiK Sato
Mar 25, 1998·Journal of Biomedical Materials Research·A J GarcíaD Boettiger
Jun 1, 1991·Journal of Biomedical Materials Research·D A PuleoR Bizios
May 1, 1994·Journal of Biomedical Materials Research·J K West, L L Hench
Mar 1, 1995·Journal of Biomedical Materials Research·Ahmed El-GhannamI M Shapiro
Oct 1, 1995·Journal of Biomedical Materials Research·M A AttawiaC T Laurencin
Jun 22, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ahmed El-GhannamI M Shapiro
May 1, 1990·Biomaterials·M CannasS Contoli
Oct 22, 2013·Dental Materials : Official Publication of the Academy of Dental Materials·Song-Yi YangKwang-Mahn Kim
Oct 16, 2003·Biosensors & Bioelectronics·Chao YangKenton R Kaufman
Nov 1, 1992·Journal of Periodontology·R M MeffertM E Fritz
Jun 1, 1993·Journal of Periodontology·S C GuyT E Van Dyke
Aug 23, 2003·Journal of Periodontology·Paul O FrancisMohamed Sharawy
Jan 21, 2014·Journal of Dentistry·Li-Na NiuFranklin R Tay
Nov 1, 1988·Journal of Biomedical Materials Research·L HäkkinenH Larjava
Oct 7, 2015·Dental Materials Journal·Andrea Corrado Profeta, Gian Marco Prucher
Jan 1, 2004·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·Jeffrey P SpalazziHelen H Lu
Jan 1, 1988·Annals of the New York Academy of Sciences·L L Hench
Nov 11, 1999·Journal of Biomedical Materials Research·H Ohgushi, A I Caplan
Oct 21, 2003·Journal of Biomedical Materials Research. Part a·Tohru HayakawaKimiya Nemoto
Jan 1, 1988·Annals of the New York Academy of Sciences·U GrossV Strunz
Jan 1, 1988·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M CannasA G Gristina
Nov 19, 2005·Expert Review of Medical Devices·Ahmed El-Ghannam
May 17, 2000·Journal of Biomedical Materials Research·M A De DiegoL L Hench

Related Concepts

Hemocompatible Materials
Bone Cements
Cell Adhesion
Prostheses and Implants

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

© 2021 Meta ULC. All rights reserved