Effect of Ficus racemosa stem bark on the activities of carbohydrate hydrolyzing enzymes: an in vitro study

Pharmaceutical Biology
Faiyaz Ahmed, Asna Urooj

Abstract

Herbal medicines have been used since prehistoric times by different cultures worldwide for the treatment of diabetes. The present investigation evaluated the effect of Ficus racemosa Linn. (Moraceae) stem bark on carbohydrate hydrolyzing enzymes, viz., porcine pancreatic alpha-amylase, rat intestinal alpha-glucosidase, sucrase, and almond beta-glucosidase, using in vitro model systems. In addition, the effect of heat treatment was also studied. Untreated F. racemosa bark (FRB) significantly inhibited (p < or = 0.05) alpha-amylase, alpha-glucosidase, beta-glucosidase, and sucrase in a dose-dependent manner. Heat treatment of the sample comparably increased alpha-amylase, alpha-glucosidase, and sucrase inhibitory activities, while a marginal decrease in beta-glucosidase inhibitory activity was observed; however, no statistical differences were noted. Untreated FRB showed IC(50) values of 0.94% and 280, 212, and 367 microg/mL for alpha-amylase, alpha-glucosidase, beta-glucosidase, and sucrase, respectively, while the IC(50) values for heat treated FRB were 0.58% and 259, 223, and 239 microg/mL, respectively. Further, a significant correlation (p < or = 0.01; r = 0.791) was observed between alpha-amylase, alpha-glucosidase, beta-g...Continue Reading

References

Jan 1, 1974·Advances in Carbohydrate Chemistry and Biochemistry·J J Marshall
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Jan 1, 1993·Bioscience, Biotechnology, and Biochemistry·M Honda, Y Hara

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Citations

Jul 30, 2010·Pharmacognosy Magazine·Faiyaz Ahmed, Asna Urooj
Jul 28, 2016·Journal of Ethnopharmacology·Saravanan V SathasivampillaiMichael Heinrich
Jun 1, 2017·Natural Product Research·Nantiya JoycharatSupayang Piyawan Voravuthikunchai
Oct 27, 2018·Frontiers in Pharmacology·Saravanan V SathasivampillaiMichael Heinrich

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