Effect of filarial infection on serum inflammatory and atherogenic biomarkers in coronary artery disease (CURES-121).

The American Journal of Tropical Medicine and Hygiene
Vivekanandhan AravindhanSubash Babu

Abstract

Helminth infections can potentially confer protection against metabolic disorders, possibly through immunomodulation. In this study, the baseline prevalence of lymphatic filariasis (LF) among subjects without (N = 236) and with (N = 217) coronary artery disease (CAD) was examined as part of the Chennai Urban Rural Epidemiological Study (CURES). The prevalence of LF was not significantly different between CAD(-) and CAD(+) subjects. The LF antigen load and antibody levels indicated comparable levels of infection and exposure between the groups. Within the CAD group, LF(+) and LF(-) subjects had no significant difference in the intimal medial thickness and high-sensitivity C-reactive protein values. However, LF infection was associated with augmented levels of tumor necrosis factor-α and interleukin-6 among CAD(+) subjects. The LF infection had no effect on serum adipocytokine profile. In conclusion, unlike type-2 diabetes, there is no association between the prevalence of LF and CAD and also no evidence of protective immunomodulation of LF infection on CAD in the Asian Indian population.

References

Nov 1, 1988·The Journal of Infectious Diseases·R B Lal, E A Ottesen
Jun 26, 2001·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·D S Bell
Dec 13, 2003·Hormone Research·Yuji MatsuzawaTohru Funahashi
Jun 28, 2005·International Journal of Cardiology·Rajeev GuptaV P Gupta
Apr 6, 2007·Gastroenterology·Meaghan M HunterDerek M McKay
Jun 5, 2007·Immunobiology·Elly van RietMaria Yazdanbakhsh
Jan 29, 2008·Current Pharmaceutical Design·Giuseppe MatareseAntonio La Cava
Aug 6, 2008·Inflammatory Bowel Diseases·Joel V Weinstock, David E Elliott
Feb 14, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Robin P Choudhury, Edward A Fisher
Dec 9, 2009·Clinical and Experimental Immunology·M M HarnettW Harnett
Dec 2, 2010·The American Journal of Tropical Medicine and Hygiene·Vivekanandhan AravindhanSubash Babu
Mar 9, 2011·Coronary Artery Disease·Hosam Hasan-AliAlaa Abd-Elsayed

❮ Previous
Next ❯

Citations

Sep 10, 2016·Journal of Diabetes Research·Vivekanandhan Aravindhan, Haridoss Madhumitha
Nov 17, 2017·The American Journal of Tropical Medicine and Hygiene·Vivekanandhan Aravindhan, Gowrishankar Anand
Nov 9, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anuradha RajamanickamSubash Babu
Sep 28, 2021·Frontiers in Immunology·Joy Manohar SibiVivekanandhan Aravindhan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.