PMID: 9540456Apr 16, 1998Paper

Effect of film composition and various penetration enhancers concentrations on prazosin release from acrylic polymeric films

Pharmaceutica acta Helvetiae
E A HosnyE M Niazy

Abstract

An investigation was conducted to evaluate the effect of changing the Eudragit RL 100 ratio and the influence of different penetration enhancers in various concentrations on the release of prazosin from Carboset 525:Eudragit RL 100 polymeric films using improved Franz diffusion cells, to choose the most suitable polymeric film ratio, the most appropriate enhancer and its optimum concentration to be used to achieve the maximum release of the drug. The results show that prazosin release from polymeric films containing Carboset 525:Eudragit RL 100 in a 1:1 ratio was significantly (p < 0.05) higher than from films in a 1:0.25 ratio and non-significantly (p > 0.05) higher than from those containing 1:0.5, 1:3 polymer ratios and non-significantly lower from those containing 1:4 polymer ratios. The addition of various enhancers, n-decyl alcohol (7, 9 and 11% w/w), Azone (4, 6 and 8% w/w) and Cineole (7, 9, 11 and 14% w/w) significantly (p < 0.05) enhanced the prazosin release from these polymeric films containing the two polymers in a 1:1 ratio. The best concentrations of these enhancers were 11% n-decyl alcohol, 9% Cineole and 8% Azone. The formulations containing these concentrations of the enhancers are being further studied for dr...Continue Reading

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Citations

Jun 8, 2002·Archives of Biochemistry and Biophysics·Vladimir Zabrouskov, N Richard Knowles
Aug 15, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ewa OledzkaWaclaw Kolodziejski
May 24, 2005·International Journal of Pharmaceutics·M J Fresno ContrerasA Ramírez Diéguez

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