Effect of fish oil on the development of AOM-induced glutathione S-transferase placental form positive hepatocellular foci in male F344 rats

Nutrition and Cancer
S SugieK Satoh

Abstract

Omega-3 fatty acids, which are contained in fish oils and certain vegetable oils in contrast to corn oil or safflower oil rich in omega-6 fatty acids (linoteic acid), have been reported to reduce the carcinogenesis in several organs. In this study, the modifying effect of menhaden fish oil was investigated on the occurrence of azoxymethane (AOM)-induced glutathione S-transferase placental form (GST-P) positive hepatocellular foci, recognized preneoplastic lesions in the liver, in male F344 rats. Starting at five weeks of age, groups of animals were fed ad libitum a semipurified diet containing 5% corn oil (low fat). At seven weeks of age, all animals except the vehicle-treated groups were injected subcutaneously with AOM (15 mg/kg body wt, 1x/wk for 2 wks). Four days after the second injection, groups of animals were fed the diets containing 4% menhaden oil + 1% corn oil (low fish oil diet), 22.5% menhaden oil + 1% corn oil (high fish oil diet), and 5% corn oil. Thirty-four weeks after AOM injections, all animals were necropsied. Livers were sectioned and performed immunohistochemical staining of GST-P for quantitative analysis of enzyme altered foci of the liver. The results demonstrate that the density and the unit area of AO...Continue Reading

References

Nov 1, 1979·Prostaglandins and Medicine·B R CulpW E Lands
Oct 1, 1979·The British Journal of Surgery·D J LeaperA Bennett
May 1, 1978·Analytical Biochemistry·M Mihara, M Uchiyama
Sep 11, 1975·Journal of the National Cancer Institute·W J BlotT R Bender
Jan 1, 1987·Advances in Cancer Research·S SellH A Dunsford
Jan 1, 1989·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·T ShimazuiY Uchiyama
Nov 1, 1989·Carcinogenesis·K SatohK Sato
Apr 1, 1986·Proceedings of the Society for Experimental Biology and Medicine·H P Glauert, H C Pitot
Jan 1, 1987·Advances in Veterinary Science and Comparative Medicine·G M Williams
Mar 1, 1987·Carcinogenesis·M A MooreK Sato
May 6, 1980·Biochimica Et Biophysica Acta·H C Pitot, A E Sirica
Jul 1, 1980·Prostaglandins and Medicine·R A Karmali
Dec 1, 1980·Psychiatry Research·C Kirkegaard, B J Carroll
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·E J CoreyJ R Cashman
Jan 1, 1980·Journal of Cancer Research and Clinical Oncology·N H Nielsen, J P Hansen

❮ Previous
Next ❯

Citations

Mar 22, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S AhmedS Sultana
Sep 8, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T IchinoseT Shibamoto
Dec 13, 2005·Cancer Treatment Reviews·Tong Wu
Sep 20, 2000·Journal of Agricultural and Food Chemistry·Y J KoH W Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.