Effect of Fish Oil Supplementation on Hepatic and Visceral Fat in Overweight Men: A Randomized Controlled Trial

Nutrients
Helen M ParkerNathan A Johnson

Abstract

Being overweight increases the risk of the development of metabolic conditions such as non-alcoholic fatty liver disease (NAFLD), which is itself an independent predictor of cardiovascular disease. Omega-3 polyunsaturated fatty acid (PUFA) supplementation is recommended for prevention of chronic disease, and is thought to reduce raised liver fat, yet there have been few randomized controlled trials with accurate measurement of liver fat. We assessed the effect of 12 weeks of supplementation with omega-3 PUFA from fish oil versus placebo on quantified liver fat, liver tests, and body composition including visceral adipose tissue (VAT) in a double-blind randomized controlled trial. Fifty apparently healthy overweight men (BMI 25.0⁻29.9 kg/m²; waist > 94 cm) were randomly allocated to consume fish oil (total daily dose: 1728 mg marine triglycerides, of which 588 mg EPA and 412 mg DHA, combined with 200 mg antioxidant, coenzyme Q10) or placebo (olive oil capsules) daily for 12 weeks. Liver fat was assessed using proton magnetic resonance spectroscopy. All outcomes were assessed at baseline and following 6 and 12 weeks of supplementation. Baseline liver fat was 4.6 ± 0.5% (range: 0.6 to 18.2%); 16 (32%) participants met the criteria...Continue Reading

References

Mar 1, 1983·The American Journal of Clinical Nutrition·C BouchardG Thériault
Nov 11, 1999·European Journal of Clinical Nutrition·K OvervadS Stender
Sep 10, 2002·JPEN. Journal of Parenteral and Enteral Nutrition·Alan Buchman
Nov 20, 2002·Circulation·Penny M Kris-EthertonUNKNOWN American Heart Association. Nutrition Committee
Jun 23, 2004·Preventive Medicine·William S Harris, Clemens Von Schacky
Sep 2, 2004·American Journal of Physiology. Endocrinology and Metabolism·Lidia S SzczepaniakRobert L Dobbins
Sep 25, 2004·Journal of Magnetic Resonance Imaging : JMRI·Vincenzo PositanoLuigi Landini
Sep 15, 2006·Atherosclerosis·Giovanni Targher, Guido Arcaro
Dec 15, 2006·Nature·Luc F Van GaalChristophe E De Block
Apr 4, 2007·Alimentary Pharmacology & Therapeutics·P Angulo
Oct 2, 2007·Journal of the American Dietetic Association·Marion J FranzNicolas P Pronk
Dec 7, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·L SpadaroF Purrello
Feb 19, 2008·Journal of Clinical Gastroenterology·Naoki TanakaToshifumi Aoyama
Apr 9, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nathan A JohnsonJacob George
Jun 6, 2008·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Gloria Lena VegaScott M Grundy
Sep 9, 2008·International Journal of Cardiology·Guy D EslickAlan Bensoussan
Feb 13, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ana González-PérizJoan Clària
Jun 26, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giovanni MussoGianfranco Pagano
Aug 21, 2012·Journal of Lipid Research·Donald B JumpSasmita Tripathy
Nov 10, 2012·World Journal of Gastroenterology : WJG·Matteo Nicola Dario Di MinnoGiovanni Tarantino
Nov 13, 2012·International Journal of Cardiology·Angel Brea, José Puzo
Sep 21, 2013·The Cochrane Database of Systematic Reviews·Mohammed E MadmaniWaleed Kadro
Oct 15, 2013·Nutrition Reviews·Michael R FlockPenny M Kris-Etherton
Feb 26, 2014·Nutrients·Clemens von Schacky
Jul 22, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Eleonora ScorlettiUNKNOWN WELCOME Study
Jun 7, 2015·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Monize Aydar NogueiraDan Linetzky Waitzberg
Jun 17, 2015·World Journal of Gastroenterology : WJG·Yun-Hua LiXian-Xian Liu

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Citations

Apr 10, 2020·Food & Function·Ronan LordanIoannis Zabetakis
Jun 17, 2020·Annual Review of Nutrition·Nishan Sudheera KalupahanaNaima Moustaid-Moussa
Dec 20, 2019·Applied Microbiology and Biotechnology·Amin GasmiGeir Bjørklund
Aug 6, 2020·Nutrients·Brittanie KilchoerLia Bally
Aug 25, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Sion A ParryLeanne Hodson
Sep 10, 2020·The Journal of Clinical Endocrinology and Metabolism·Terezie ČížkováMichaela Šiklová
Feb 12, 2021·International Journal of Environmental Research and Public Health·Małgorzata MoszakPaweł Bogdański
Mar 4, 2021·Nutrients·Roberta Dourado Cavalcante da Cunha de SáMaria Isabel Alonso-Vale
May 10, 2021·BMC Sports Science, Medicine and Rehabilitation·Sara MoradiBeitullah Alipour
Apr 29, 2021·Molecular Nutrition & Food Research·Stefan KabischAndreas F H Pfeiffer

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Methods Mentioned

BETA
blood collection

Software Mentioned

jMRUI
Foodworks TM
HippoFat TM
Xyris
Statistical Package for the Social Sciences
SPSS

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