Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription

Mutation Research
Karen A O'LearyGary Williamson

Abstract

Cyclooxygenase-2 (COX-2)-catalysed synthesis of prostaglandin E2 plays a key role in inflammation and its associated diseases, such as cancer and cardiovascular disease. There are numerous reports demonstrating that flavonoids inhibit COX-2 activity. However, transcriptional regulation of COX-2 can also be important. Nobiletin, amentoflavone, quercetin, quercetin penta-acetate, flavone, resveratrol, apigenin, chrysin, kaempferol, galangin, and genistein have been reported to modulate COX-2 transcription in a wide variety of systems. Here, we briefly review the literature on regulation of COX-2 transcription by flavonoids, and report some new preliminary data on Vitamin E and quercetin conjugates. Quercetin, quercetin 3-glucuronide, quercetin 3'-sulfate and 3'methylquercetin 3-glucuronide reduced COX-2 mRNA expression in both unstimulated and interleukin-1beta stimulated colon cancer (Caco2) cells. Quercetin and quercetin 3'-sulfate, unlike quercetin 3-glucuronide and 3'methylquercetin 3-glucuronide, also inhibited COX-2 activity. In contrast, tocopherols (alpha-tocopherol, alpha-tocopherol acetate, and gamma-tocopherol at 10microM) did not affect COX-2 mRNA expression in unstimulated Caco2 cells. However, the tocopherols inhibi...Continue Reading

References

Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M K O'BanionD A Young
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·K K WuD S Loose-Mitchell
Jan 1, 1991·Annals of the New York Academy of Sciences·A S Hamblin
Apr 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J C KipsR A Pauwels
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·H KellerW Wahli
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·X M XuK K Wu
Sep 27, 2000·Proceedings of the National Academy of Sciences of the United States of America·Q JiangB N Ames
Jul 30, 2002·Prostaglandins, Leukotrienes, and Essential Fatty Acids·T BanerjeeV A Ziboh
Feb 28, 2004·The Journal of Nutrition·Sonia de Pascual-TeresaGary Williamson

❮ Previous
Next ❯

Citations

Oct 12, 2007·Nutrition and Cancer·Nanjoo SuhHarold L Newmark
Sep 16, 2008·Nutrition and Cancer·W Elaine Hardman, Gabriela Ion
Jan 14, 2011·Critical Reviews in Food Science and Nutrition·Letitia M McCuneCynthia A Thomson
Mar 6, 2013·Antioxidants & Redox Signaling·Ann M Bode, Zigang Dong
Dec 5, 2008·Journal of Medicinal Food·Enguo FanYuhua Bai
Sep 15, 2009·Carcinogenesis·Jihyeung JuChung S Yang
Jul 4, 2008·Journal of Leukocyte Biology·Dayong Wu, Simin Nikbin Meydani
May 19, 2010·International Journal of Molecular Sciences·Massimo D'ArchivioRoberta Masella
Feb 23, 2011·International Journal of Molecular Sciences·Elizabeth A MazzioKaram F A Soliman
Aug 29, 2006·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Tomas FlorianTomas Bartosik
Mar 26, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·João Henrique G LagoCarla M Prado
Jun 17, 2008·European Journal of Nutrition·Theo M de KokMargaret M Manson
Jul 2, 2009·Nutrition Reviews·Béatrice RomierAlexandrine During
Sep 23, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vernon W Dolinsky, Jason R B Dyck
Feb 24, 2016·Frontiers in Pharmacology·Valeria ContiAmelia Filippelli
Jun 1, 2012·PM & R : the Journal of Injury, Function, and Rehabilitation·Hector L Lopez
Jan 10, 2012·The Journal of Nutritional Biochemistry·Jae Min ChoMyung-Jun Kim
Sep 20, 2011·Current Opinion in Biotechnology·Maria Daglia
Aug 23, 2011·Biochemical Pharmacology·Maria RussoGian Luigi Russo
Dec 29, 2015·Journal of Molecular Graphics & Modelling·Jintawee KicuntodThanyada Rungrotmongkol
Jan 10, 2012·Journal of Food Composition and Analysis : an Official Publication of the United Nations University, International Network of Food Data Systems·Janice E MarasKatherine L Tucker
Feb 26, 2016·Journal of Dermatological Science·Xiaolin RenXiyun Ye
Feb 24, 2007·Molecular Aspects of Medicine·Elke ReiterStephan Christen
Jun 1, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Hae-Ryung Park, Rita Loch-Caruso
Jun 13, 2009·Alcoholism, Clinical and Experimental Research·Lindsay BrownPeter Feick
Jun 27, 2007·Alimentary Pharmacology & Therapeutics·I T Johnson, E K Lund
Jan 26, 2011·Annals of the New York Academy of Sciences·Goran PetrovskiDipak K Das
Sep 8, 2010·Chemico-biological Interactions·Thérèse SergentYves-Jacques Schneider

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here